Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Biocatalyst for the production of 25-OH-Vitamin D3 and other derivatives by recombinant Bacillus megaterium strains

06.10.2015

Background The biotechnological production of 25-OH Vitamin D3 is of great importance, as this inactivated position 25 within vitamin D3 is hardly achievable by means of organic synthesis, especially in terms of a regio- and stereoselective manner. Within the human body, 25-OH vitamin D3 is converted into the biological active form of vitamin D3 which is important for the Ca2+ deposit into bones. Furthermore, in case of hepatic cirrhosis, its substitution is essential. It has anti-carcinogenic effects and acts protective in terms of autoimmune and cardiovascular diseases. 25-OH vitamin D3 is also used as a standard in clinical laboratory diagnostics. Altogether, 25-OH vitamin D3 is valuable concerning biotechnology, pharmacy and medicine. Invention Biochemists of Saarland University identified and optimized two cytochrome P450 systems which are capable of performing a regio- and stereoselective hydroxylation of vitamin D3 in one step, transferring vitamin D3 to 25-OH and other hydroxyl- derivatives of vitamin D3. The enzymes belong to the CYP109 family. One of these enzymes is capable of synthesizing 25-OH vitamin D3 as a major product and three side products in vitro producing a yield of 26 mg/l/24h. The second one gives rise to 25-OH vitamin D3 as the only product producing a yield of 5 mg/l/24h. Advantages • Synthesis of 25-OH vitamin D3 and other hydroxyl-derivatives in high yields o 25-OH vitamin D3 and three side products→ 26 mg/l/24h o 25-OH vitamin D3 → 5 mg/l/24h • Low production costs • No toxic side products as in classical organic synthesis

Further information: PDF

Universität des Saarlandes Wissens- und Technologietransfer GmbH PatentVerwertungsAgentur der saarländischen Hochschulen
Phone: +49 (0)681/302-71302

Contact
Dr. Conny Clausen, Dr. Nicole Comtesse, Dr. Frank Döbrich, Dr. Susanne Heiligenstein, Dr. Christof Schäfer

As Germany's association of technology- and patenttransfer agencies TechnologieAllianz e.V. is offering businesses access to the entire range of innovative research results of almost all German universities and numerous non-university research institutions. More than 2000 technology offers of 14 branches are beeing made accessable to businesses in order to assure your advance on the market. At www.technologieallianz.de a free, fast and non-bureaucratic access to all further offers of the German research landscape is offered to our members aiming to sucessfully transfer technologies.

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=04321&lang=en
http://www.technologieallianz.de/

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>