The development of receptor tyrosine-kinase inhibitors (TKIs) in recent decades was a major step forward in cancer treatment. However, despite their clinical efficacy, therapy with TKIs is limited by strong side effects (such as skin rash) and development of resistance. New approaches are required to overcome these drawbacks. Complexing the TK Inhibitor with Cobalt (Co3+) inactivates the inhibitor until it is released under the hypoxic conditions in the target tumour tissue. This approach promises effective treatment with considerably limited side effects. These complexes can be used as an alternative to existing Epidermal Growth Factor Receptor (EGFR) Inhibitors, and were effective in tumour cells that have become resistant to conventional Treatments due to EGFR mutations like T790M.
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