Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

What makes pancreatic cancer so aggressive?

18.04.2017

FAU researchers discover key factor for the aggressiveness of pancreatic cancer

Pancreatic cancer is one of the most aggressive tumour types because it starts forming metastases early. The cancer itself, however, is usually only discovered late.

This leads to a high patient mortality rate. Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have now discovered why pancreatic cancer and other malignant types of tumours can disseminate so rapidly. The results have now been published in the renowned journal Nature Cell Biology.

The FAU researchers led by Prof. Dr Thomas Brabletz and Dr. Marc Stemmler of the Chair of Experimental Medicine I, with the cooperation of the Department of Medicine 5 – Haematology and Oncology, the Department of Surgery at Universitätsklinikum Erlangen, and the Chair of Genetics at the Faculty of Sciences, have discovered that this aggressive type of tumour activates the key factor of an embryonic programme.

This factor, called Zeb1, controls how cells migrate and survive in early embryonic development. Zeb1 is blocked in normal, fully developed cells. But when the factor is re-activated in cancer cells, it has fatal consequences:

The tumour cells disseminate throughout the body and quickly adapt to the changing conditions in their new environment. They can then develop into metastases and form secondary tumours. The cancer assumes an aggressive progression.

If, however, Zeb1 is not activated, cancer cells can no longer adapt to their new environment so easily. This in turn leads to the development of a variant of pancreatic cancer which presents significantly lower metastatic capacity.

This mechanism is also observed in other tumours, such as aggressive forms of breast cancer. The researchers now hope these findings will help them to develop new treatment strategies for combating metastases of pancreatic cancer and other aggressive tumour types.

Original publication:
Angela M. Krebs, Julia Mitschke, Maria Lasierra Losada, Otto Schmalhofer, Melanie Boerries, Hauke Busch, Martin Boettcher, Dimitrios Mougiakakos, Winfried Reichardt, Peter Bronsert, Valerie G. Brunton, Thomas H. Winkler, Simone Brabletz, Marc P. Stemmler and Thomas Brabletz. The EMT activator ZEB1 is a key factor for cellular plasticity and promotes metastasis in pancreatic cancer. Nat Cell Biol, DOI 10.1038/ncb3513 (2017).

Comment:
M. A. Nieto. News and Views: Context-specific roles of EMT programmes in cancer cell dissemination. Nat Cell Biol, Vol 19 (May 2017).

Further information:
Prof. Dr. Thomas Brabletz
Thomas.brabletz@fau.de

Boris Mijat | idw - Informationsdienst Wissenschaft
Further information:
http://www.fau.de/

More articles from Health and Medicine:

nachricht GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University

nachricht Scientists re-create brain neurons to study obesity and personalize treatment
20.04.2018 | Cedars-Sinai Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Structured light and nanomaterials open new ways to tailor light at the nanoscale

23.04.2018 | Physics and Astronomy

On the shape of the 'petal' for the dissipation curve

23.04.2018 | Physics and Astronomy

Clean and Efficient – Fraunhofer ISE Presents Hydrogen Technologies at the HANNOVER MESSE 2018

23.04.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>