Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UT-research: better outcome prediction of postanoxic coma

23.06.2015

EEG-measurements enable better prediction of the outcome of a coma that was caused by a lack of oxygen to the brain. This became clear from research of the University of Twente (MIRA) in cooperation with Rijnstate hospital and MST.

A new method helps to make reliable and correct estimates in about 50% of patients, instead of only 10% of patients with the methods currently used. This involves continuous EEG-measurements focussing on the speed with which the brain's activity recovers. It seems that recovery over time is a better indicator of the severity of brain damage than single brief measurements, which are currently done.

Half of the patients with a post-anoxic coma (a coma resulting from lack of oxygen to the brain) never regain consciousness. It is exceptionally difficult to reliably predict which patients are and which are not capable of recovering. Currently, prediction is based on clinical measurements of the depth of the coma in combination with a so-called SSEP measurement. This provides a correct estimate for only ten percent of patients. This is why doctor, and also family-members, need an instrument that is better at determining which patients do and which do not have a chance of recovery.

First 24 hours

Performing a continuous EEG measurement and looking at improvement of brain activity allows a correct estimate in half of the patients. This is shown by research of the University of Twente in cooperation with Rijnstate hospital and Medisch Spectrum Twente.

The published research, which involves data from approximately 300 patients, was carried out during the period from 2011 to 2014. This is the largest dataset ever used for research of EEG in postanoxic coma. According to the first author, dr. Jeannette Hofmeijer (assistant professor at the University of Twente and neurologist at Rijnstate hospital), who set up this research together with prof. dr. ir. Michel van Putten (chairholder Clinical Neurophysiology at the UT and neurologist/clinical neurophysiologist at the MST), EEG based outcome prediction showed less reliable results in previous studies. In the current study, prediction improved importantly by looking at the EEG differently.

Instead of using a single EEG measurement, EEG measurements were now made continuously. A single measurement provides insufficient reliable information about the severity of the brain damage and the chance of recovery. Otherwise, by looking at changes in brain activity over time, much more information can be obtained from the EEG.

Improvement of brain activity measured in the first 24 hours is crucial: if there is sufficient improvement within twelve hours, a good recovery can be predicted with a high level of probability, while the prognosis is invariably poor if there is insufficient improvement within 24 hours. Being able to determine the chance of recovery at an early stage provides doctors and families with better information about whether continuation of intensive care treatment makes sense.

Research
The research was initiated and set up by dr. Jeannette Hofmeijer and prof. dr. ir. Michel van Putten and carried out in cooperation with Tim Beernink (medical doctor at Rijnstate), dr. Frank Bosch (intensivist Rijnstate), dr. Albertus Beishuizen (intensivist MST) and dr. Marleen Tjepkema-Cloostermans (technical medicine UT and MST). The research was partly funded by the Dutch Ministry of Economic Affairs, Agriculture and Innovation, province Overijssel and Gelderland (ViP Brain Networks project). Marleen Tjepkema-Cloostermans obtained het PhD in the subject at the University of Twente in 2014.

Medical-ethical questions
This improvement in diagnostics is a step forward, but means doctors and family-members are faced with new important medical-ethical questions. Such as: when are the prospects of a coma-patient so poor that stopping treatment is justified? In a new study, doctors and philosophers at the UT's MIRA research institute will start searching for answers to these and other ethical questions. That study will start in the middle of this year and is being funded by the Netherlands Organization for Scientific Research (NWO), the Netherlands Brain Foundation, Clinical Science Systems and Twente Medical Systems International.

Note for the press
For more information, interview requests, or a digital version of the article Early EEG contributes to multimodal outcome prediction of postanoxic coma, please contact the UT Science Information Officer, Joost Bruysters (06 1048 8228).

drs Joost Bruysters | idw - Informationsdienst Wissenschaft
Further information:
http://www.utwente.nl/en/research/

Further reports about: EEG activity brain damage early stage ethical questions measurement

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>