Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UT-research: better outcome prediction of postanoxic coma

23.06.2015

EEG-measurements enable better prediction of the outcome of a coma that was caused by a lack of oxygen to the brain. This became clear from research of the University of Twente (MIRA) in cooperation with Rijnstate hospital and MST.

A new method helps to make reliable and correct estimates in about 50% of patients, instead of only 10% of patients with the methods currently used. This involves continuous EEG-measurements focussing on the speed with which the brain's activity recovers. It seems that recovery over time is a better indicator of the severity of brain damage than single brief measurements, which are currently done.

Half of the patients with a post-anoxic coma (a coma resulting from lack of oxygen to the brain) never regain consciousness. It is exceptionally difficult to reliably predict which patients are and which are not capable of recovering. Currently, prediction is based on clinical measurements of the depth of the coma in combination with a so-called SSEP measurement. This provides a correct estimate for only ten percent of patients. This is why doctor, and also family-members, need an instrument that is better at determining which patients do and which do not have a chance of recovery.

First 24 hours

Performing a continuous EEG measurement and looking at improvement of brain activity allows a correct estimate in half of the patients. This is shown by research of the University of Twente in cooperation with Rijnstate hospital and Medisch Spectrum Twente.

The published research, which involves data from approximately 300 patients, was carried out during the period from 2011 to 2014. This is the largest dataset ever used for research of EEG in postanoxic coma. According to the first author, dr. Jeannette Hofmeijer (assistant professor at the University of Twente and neurologist at Rijnstate hospital), who set up this research together with prof. dr. ir. Michel van Putten (chairholder Clinical Neurophysiology at the UT and neurologist/clinical neurophysiologist at the MST), EEG based outcome prediction showed less reliable results in previous studies. In the current study, prediction improved importantly by looking at the EEG differently.

Instead of using a single EEG measurement, EEG measurements were now made continuously. A single measurement provides insufficient reliable information about the severity of the brain damage and the chance of recovery. Otherwise, by looking at changes in brain activity over time, much more information can be obtained from the EEG.

Improvement of brain activity measured in the first 24 hours is crucial: if there is sufficient improvement within twelve hours, a good recovery can be predicted with a high level of probability, while the prognosis is invariably poor if there is insufficient improvement within 24 hours. Being able to determine the chance of recovery at an early stage provides doctors and families with better information about whether continuation of intensive care treatment makes sense.

Research
The research was initiated and set up by dr. Jeannette Hofmeijer and prof. dr. ir. Michel van Putten and carried out in cooperation with Tim Beernink (medical doctor at Rijnstate), dr. Frank Bosch (intensivist Rijnstate), dr. Albertus Beishuizen (intensivist MST) and dr. Marleen Tjepkema-Cloostermans (technical medicine UT and MST). The research was partly funded by the Dutch Ministry of Economic Affairs, Agriculture and Innovation, province Overijssel and Gelderland (ViP Brain Networks project). Marleen Tjepkema-Cloostermans obtained het PhD in the subject at the University of Twente in 2014.

Medical-ethical questions
This improvement in diagnostics is a step forward, but means doctors and family-members are faced with new important medical-ethical questions. Such as: when are the prospects of a coma-patient so poor that stopping treatment is justified? In a new study, doctors and philosophers at the UT's MIRA research institute will start searching for answers to these and other ethical questions. That study will start in the middle of this year and is being funded by the Netherlands Organization for Scientific Research (NWO), the Netherlands Brain Foundation, Clinical Science Systems and Twente Medical Systems International.

Note for the press
For more information, interview requests, or a digital version of the article Early EEG contributes to multimodal outcome prediction of postanoxic coma, please contact the UT Science Information Officer, Joost Bruysters (06 1048 8228).

drs Joost Bruysters | idw - Informationsdienst Wissenschaft
Further information:
http://www.utwente.nl/en/research/

Further reports about: EEG activity brain damage early stage ethical questions measurement

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>