Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The gut microbiota can influence the effectiveness of dietary treatments

11.11.2015

Why a dietary treatment works for some but not others seems to depend on interactions between the gut microbiota and the diet. A new study, published in Cell Metabolism, shows that people with better control of blood sugar after eating barley kernel bread also have a different balance of microbes in the gut.

Dietary interventions can be used to improve the metabolism of humans, and they also have a major impact on the gut microbiota. Previous studies at the Sahlgrenska Academy have shown that the gut microbiota is altered in metabolic diseases such as type 2 diabetes, and that the gut microbiota contributes to obesity, diabetes and cardiovascular disease.


Fredrik Bäckhed, professor at the Sahlgrenska Academy and Director of the Wallenberg Laboratory, University of Gothenburg

University of Gothenburg

Barley kernel bread
In a new study, 39 subjects ate barley kernel bread for three days followed by control bread made from white flour for three days (with a break between the two diets). The results showed that barley kernel bread improved the control of blood sugar, but only in some individuals.

Gut microbiota
Prevotella, a group of bacteria previously shown to be associated with high fiber intake, was present in higher proportions in those who responded beneficially to barley kernel bread than in those who did not respond to this dietary intervention.

By transferring the gut microbiota of these individuals to germ-free mice, the research group could demonstrate that the altered gut microbiota contributed to the beneficial effects of the barley kernel bread.

Metabolism
“Our findings clearly show the importance of the interaction between the gut microbiota and the diet and contribute to our understanding of metabolism in health and disease. The results may help to explain why responses to different dietary treatments are so individual,” says Professor Fredrik Bäckhed at the Sahlgrenska Academy, University of Gothenburg.

Lund University participated
Bread with different fibers has attracted considerable interest and is a focus area at the Antidiabetic Food Center at Lund University (a VINN Excellence Center), which participated in the study.

“It is incredibly exciting to see the link between the gut microbiota and various dietary fibers, which can help us develop more individualized dietary guidelines,” says Professor Inger Björk at Lund University.

Further studies
The researchers are now planning further studies and hope to confirm if the gut microbiota can identify which individuals will respond to a specific diet.

“Our results also show that control of blood sugar is improved in mice supplemented with Prevotella if they are given a high-fiber diet. Our findings could lead to a combination product with Prevotella and fiber from grains,” says Fredrik Bäckhed at the Sahlgrenska Academy.

The article Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella is published in Cell Metabolism:
http://www.sciencedirect.com/science/article/pii/S1550413115005173

Contact:
Fredrik Bäckhed, professor at the Sahlgrenska Academy and Director of the Wallenberg Laboratory, University of Gothenburg
fredrik.backhed@wlab.gu.se

Inger Björck, professor at Lund University, Center for Preventive Food Research
inger.bjorck@food-health-science.lu.se

Weitere Informationen:

http://sahlgrenska.gu.se/english/research/news-article/?languageId=100001&co...

Calle Björned | idw - Informationsdienst Wissenschaft

Further reports about: Metabolism Prevotella blood sugar kernel microbiota

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>