Healthy, elderly research participants who report being more sleepy and less rested have higher levels of amyloid deposition in regions of the brain that are affected in Alzheimer's disease, according to a report presented today at the American College of Neuropsychopharmacology annual meeting in Phoenix (Arizona). If sleep disturbance is a cause of amyloid accumulation, it may be an early target for intervention to prevent the progression of cognitive deficits in late life.
Numerous studies have shown the importance of sleep and the effect that sleep deprivation can have on our brains. Sleep apnea is associated with cognitive dysfunction across the lifespan and both untreated apnea and sleep disturbance are associated with increased cognitive dysfunction in patients with Alzheimer's disease. Evaluating physical changes in the brain and how they are related to sleep quality can help determine the extent to which sleep can provide a window on brain function and pathology.
Using positron emission tomography (PET) scanning with a tracer that visualizes deposits of amyloid, a protein that is elevated in the brains of Alzheimer's disease patients, Ruth Benca and her colleagues at the University of Wisconsin-Madison studied the relationship between sleep quality and brain amyloid levels in a group of 98 cognitively healthy volunteers, 50-73 years of age.
The subjects, who were participants in the Wisconsin Registry for Alzheimer's Prevention, completed questionnaires about their sleep and problems related to it. Those who reported greater sleepiness showed greater amyloid acumulation in areas of the cerebral cortex that are heavily affected in Alzheimer's disease ─ the supramarginal and frontal medial orbital areas. Higher amyloid in these regions was also linked to less restful sleep and more sleep problems.
Although it is tantalizing to speculate that the link between sleep disturbances and amyloid deposition in the brain may help us identify an early, modifiable marker for Alzheimer's disease, it is too soon to draw that conclusion. "We still need to determine whether sleep disturbance promotes amyloid deposition in the brain, or if a neurodegenerative process produces disordered sleep", commented Dr. Benca. Future work is needed to answer that question and to determine whether interventions that improve sleep can prevent brain changes that lead to Alzheimer's disease.
This research was supported by funding from the National Institutes of Health: National Institute on Aging, National Institute of General Medical Sciences, and the Clinical and Translational Science Award Program.
Public relations Contact
Susan Lambert Smith
ACNP, founded in 1961, is a professional organization of more than 700 leading scientists, including four Nobel Laureates. The mission of ACNP is to further research and education in neuropsychopharmacology and related fields in the following ways: promoting the interaction of a broad range of scientific disciplines of brain and behavior in order to advance the understanding of prevention and treatment of disease of the nervous system including psychiatric, neurological, behavioral and addictive disorders; encouraging scientists to enter research careers in fields related to these disorders and their treatment; and ensuring the dissemination of relevant scientific advances.
Beth Miller | EurekAlert!
Once invincible superbug squashed by 'superteam' of antibiotics
22.08.2017 | University at Buffalo
Chronic stress induces fatal organ dysfunctions via a new neural circuit
21.08.2017 | Hokkaido University
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
22.08.2017 | Physics and Astronomy
22.08.2017 | Power and Electrical Engineering
22.08.2017 | Medical Engineering