Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists pinpoint bladder cancer patients who could benefit from 'tumor-softening' treatment

31.07.2014

Scientists in Manchester have identified a protein that could help doctors decide which bladder cancer patients would benefit from a treatment that makes radiotherapy more effective, according to a study* published in the British Journal of Cancer (BJC).

The team from The University of Manchester, funded by the Medical Research Council, found that patients whose bladder tumour had high levels of a protein, called 'HIF-1α', were more likely to benefit from having carbogen – oxygen mixed with carbon dioxide gas – and nicotinamide tablets at the same time as their radiotherapy. The treatment, called 'CON', makes radiotherapy more effective.

By comparing levels of HIF-1α in tissue samples from 137 patients who had radiotherapy on its own or with CON, the researchers found the protein predicted which patients benefited from having CON. High levels of the protein were linked to better survival from the disease when patients had radiotherapy and CON. Patients with low protein levels did not benefit from having CON with their radiotherapy.

... more about:
»Cancer »PCT »Source »benefit »diagnosed »radiotherapy »tumour

The HIF-1α protein indicates low oxygen levels in tumour cells – a state known as 'hypoxia'. The CON treatment works by adding oxygen to the oxygen-deprived tumour cells which makes them more sensitive to the radiotherapy.

Study author, Professor Catharine West, a Cancer Research UK scientist at The University of Manchester, said: "Although we have another biomarker that can predict responsiveness to CON and radiotherapy in bladder cancer patients, our findings tell us a bit more about the characteristics of bladder cancer tumours and how they may respond to this treatment."

"But we desperately need to do more work to find ways to treat those patients who won't see as much benefit from this.

"And it's exactly this type of vital research that we and other scientists will be doing at the Manchester Cancer Research Centre – bringing together a wide range of expertise to revolutionise cancer treatment."

Around 65 people are diagnosed with bladder cancer in Manchester every year**. There are around 25 deaths from the disease every year***.

Nell Barrie, senior science communications manager at Cancer Research UK, said: "This fascinating new finding could help doctors adapt their treatments to patients with bladder cancer as well as shedding more light on the disease.

"Deaths from bladder cancer are falling in the UK, but more work needs to be done so that this trend continues. More research is needed to helps us find new and better ways to fight bladder cancer."

###

For media enquiries please contact the press office on 020 3469 8300 or, out-of-hours, the duty press officer on 07050 264 059.

References

*Hunter, BA et al. Expression hypoxia-inducible factor-1α predicts benefit from hypoxia modification in invasive bladder cancer (2014) British Journal of Cancer. doi: 10.1038/bjc.2014.315

Notes to Editor

The study was supported by Medical Research Council (MRC) and Cancer Research UK Experimental Cancer Medicine Centre funding.

** The annual average number of people diagnosed with bladder cancer (ICD-10 C67) in Manchester PCT between 2008 and 2010. Source: NCIN e-atlas. http://www.ncin.org.uk/cancer_information_tools/eatlas/pct/atlas.html?se...

*** Based on the annual average number of people who died from bladder cancer (ICD-10 C67) in Manchester PCT between 2009 and 2011. Source: NCIN e-atlas. http://www.ncin.org.uk/cancer_information_tools/eatlas/pct/atlas.html?se...

Flora Malein | Eurek Alert!

Further reports about: Cancer PCT Source benefit diagnosed radiotherapy tumour

More articles from Health and Medicine:

nachricht UT Southwestern scientists discover new clues to how weight loss is regulated
24.10.2014 | UT Southwestern Medical Center

nachricht Bipolar Disorder Discovery at the Nano Level
23.10.2014 | Northwestern University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

Comparing Apples and Oranges? A Colloquium on International Comparative Urban Research

22.10.2014 | Event News

Battery Conference April 2015 in Aachen

16.10.2014 | Event News

Experts discuss new developments in the field of stem cell research and cell therapy

10.10.2014 | Event News

 
Latest News

Precise and programmable biological circuits

24.10.2014 | Life Sciences

Desert Streams: Deceptively Simple

24.10.2014 | Earth Sciences

Modernized stainless steel continuous caster from Siemens goes on stream at Posco

24.10.2014 | Press release

VideoLinks
B2B-VideoLinks
More VideoLinks >>>