Scientists in Manchester have identified a protein that could help doctors decide which bladder cancer patients would benefit from a treatment that makes radiotherapy more effective, according to a study* published in the British Journal of Cancer (BJC).
The team from The University of Manchester, funded by the Medical Research Council, found that patients whose bladder tumour had high levels of a protein, called 'HIF-1α', were more likely to benefit from having carbogen – oxygen mixed with carbon dioxide gas – and nicotinamide tablets at the same time as their radiotherapy. The treatment, called 'CON', makes radiotherapy more effective.
By comparing levels of HIF-1α in tissue samples from 137 patients who had radiotherapy on its own or with CON, the researchers found the protein predicted which patients benefited from having CON. High levels of the protein were linked to better survival from the disease when patients had radiotherapy and CON. Patients with low protein levels did not benefit from having CON with their radiotherapy.
The HIF-1α protein indicates low oxygen levels in tumour cells – a state known as 'hypoxia'. The CON treatment works by adding oxygen to the oxygen-deprived tumour cells which makes them more sensitive to the radiotherapy.
Study author, Professor Catharine West, a Cancer Research UK scientist at The University of Manchester, said: "Although we have another biomarker that can predict responsiveness to CON and radiotherapy in bladder cancer patients, our findings tell us a bit more about the characteristics of bladder cancer tumours and how they may respond to this treatment."
"But we desperately need to do more work to find ways to treat those patients who won't see as much benefit from this.
"And it's exactly this type of vital research that we and other scientists will be doing at the Manchester Cancer Research Centre – bringing together a wide range of expertise to revolutionise cancer treatment."
Around 65 people are diagnosed with bladder cancer in Manchester every year**. There are around 25 deaths from the disease every year***.
Nell Barrie, senior science communications manager at Cancer Research UK, said: "This fascinating new finding could help doctors adapt their treatments to patients with bladder cancer as well as shedding more light on the disease.
"Deaths from bladder cancer are falling in the UK, but more work needs to be done so that this trend continues. More research is needed to helps us find new and better ways to fight bladder cancer."
For media enquiries please contact the press office on 020 3469 8300 or, out-of-hours, the duty press officer on 07050 264 059.
*Hunter, BA et al. Expression hypoxia-inducible factor-1α predicts benefit from hypoxia modification in invasive bladder cancer (2014) British Journal of Cancer. doi: 10.1038/bjc.2014.315
Notes to Editor
The study was supported by Medical Research Council (MRC) and Cancer Research UK Experimental Cancer Medicine Centre funding.
** The annual average number of people diagnosed with bladder cancer (ICD-10 C67) in Manchester PCT between 2008 and 2010. Source: NCIN e-atlas. http://www.ncin.org.uk/cancer_information_tools/eatlas/pct/atlas.html?se...
*** Based on the annual average number of people who died from bladder cancer (ICD-10 C67) in Manchester PCT between 2009 and 2011. Source: NCIN e-atlas. http://www.ncin.org.uk/cancer_information_tools/eatlas/pct/atlas.html?se...
Flora Malein | Eurek Alert!
The Glowing Brain
26.07.2016 | Fraunhofer MEVIS - Institut für Bildgestützte Medizin
Nanoparticle versus cancer
21.07.2016 | Lomonosov Moscow State University
Transparent electronics devices are present in today’s thin film displays, solar cells, and touchscreens. The future will bring flexible versions of such devices. Their production requires printable materials that are transparent and remain highly conductive even when deformed. Researchers at INM – Leibniz Institute for New Materials have combined a new self-assembling nano ink with an imprint process to create flexible conductive grids with a resolution below one micrometer.
To print the grids, an ink of gold nanowires is applied to a substrate. A structured stamp is pressed on the substrate and forces the ink into a pattern. “The...
A new Fraunhofer MEVIS method conveys medical interrelationships quickly and intuitively with innovative visualization technology
On the monitor, a brain spins slowly and can be examined from every angle. Suddenly, some sections start glowing, first on the side and then the entire back of...
Researchers at the U.S. Department of Energy's (DOE) Ames Laboratory have discovered an unusual property of purple bronze that may point to new ways to achieve high temperature superconductivity.
While studying purple bronze, a molybdenum oxide, researchers discovered an unconventional charge density wave on its surface.
Munich Physicists have developed a novel electron microscope that can visualize electromagnetic fields oscillating at frequencies of billions of cycles per second.
Temporally varying electromagnetic fields are the driving force behind the whole of electronics. Their polarities can change at mind-bogglingly fast rates, and...
Breakup of continents with two speed: Continents initially stretch very slowly along the future splitting zone, but then move apart very quickly before the onset of rupture. The final speed can be up to 20 times faster than in the first, slow extension phase.phases
Present-day continents were shaped hundreds of millions of years ago as the supercontinent Pangaea broke apart. Derived from Pangaea’s main fragments Gondwana...
15.07.2016 | Event News
15.07.2016 | Event News
11.07.2016 | Event News
26.07.2016 | Life Sciences
26.07.2016 | Life Sciences
26.07.2016 | Health and Medicine