Gelatin’s short peptides - glyprolines – consist of amino acids of glycine and proline. It is them that protect the stomach mucous tunic from injuries. The highest antiulcer activity was discovered by the researchers with the PGP-sequence peptide: proline, glycine, proline. Glyprolines are easily absorbed in the stomach and remain in the blood for a long time without breaking up. They act not only on the stomach cells but also on the central nervous system overcoming the blood-brain barrier, therefore they cure even the ulcers caused by stress.
Glyprolines are natural peptides. They are generated in the organism in the course of collagen synthesis or decomposition. During the experiments carried out by the Moscow biologists, gelatin (partly hydrolyzed collagen) added to rats’ feed partly protected the rats from ulcer. Further experiments were carried out by the researchers with gelatin hydrolysate. Processing gelatin by hydrochloric acid imitates the process taking place in the stomach. After gelatin hydrolysis was performed, the researchers educed and refined about 30 short peptides, also including glyprolines.
It has turned out that gelatin peptides reinforce resistance of the stomach mucous tunic to ethanol and stress action, decreasing the ulcer area by twice. If peptides are introduced to the animals with already developed ulcer, it will also close quicker. Therapeutic effect was revealed by peptides not only in case of intraperitoneal introduction but also in case of intragastric introduction, this method being even more effective.
The researchers point out that gelatin hydrolysate produces protective and medicinal effect comparable to the action of pure PGP peptide, which is currently known as the most active glyproline. In the researchers’ opinion, not only the above-mentioned glyprolines but also short peptides unknown so far participate in the antiulcer action of gelatin peptides. Therefore, to produce the most promising protective and medicinal antiulcer drugs, the researchers are planning to investigate the action of all substances that make part of gelatin hydrolysate.
Nadezda Markina | alfa
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.
The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
29.05.2017 | Life Sciences
29.05.2017 | Physics and Astronomy
29.05.2017 | Statistics