Gelatin’s short peptides - glyprolines – consist of amino acids of glycine and proline. It is them that protect the stomach mucous tunic from injuries. The highest antiulcer activity was discovered by the researchers with the PGP-sequence peptide: proline, glycine, proline. Glyprolines are easily absorbed in the stomach and remain in the blood for a long time without breaking up. They act not only on the stomach cells but also on the central nervous system overcoming the blood-brain barrier, therefore they cure even the ulcers caused by stress.
Glyprolines are natural peptides. They are generated in the organism in the course of collagen synthesis or decomposition. During the experiments carried out by the Moscow biologists, gelatin (partly hydrolyzed collagen) added to rats’ feed partly protected the rats from ulcer. Further experiments were carried out by the researchers with gelatin hydrolysate. Processing gelatin by hydrochloric acid imitates the process taking place in the stomach. After gelatin hydrolysis was performed, the researchers educed and refined about 30 short peptides, also including glyprolines.
It has turned out that gelatin peptides reinforce resistance of the stomach mucous tunic to ethanol and stress action, decreasing the ulcer area by twice. If peptides are introduced to the animals with already developed ulcer, it will also close quicker. Therapeutic effect was revealed by peptides not only in case of intraperitoneal introduction but also in case of intragastric introduction, this method being even more effective.
The researchers point out that gelatin hydrolysate produces protective and medicinal effect comparable to the action of pure PGP peptide, which is currently known as the most active glyproline. In the researchers’ opinion, not only the above-mentioned glyprolines but also short peptides unknown so far participate in the antiulcer action of gelatin peptides. Therefore, to produce the most promising protective and medicinal antiulcer drugs, the researchers are planning to investigate the action of all substances that make part of gelatin hydrolysate.
Nadezda Markina | alfa
Antibiotic effectiveness imperiled as use in livestock expected to increase
27.03.2015 | Princeton University
A human respiratory tissue model to assess the toxicity of inhaled chemicals and pollutants
26.03.2015 | R&D at British American Tobacco
In an experiment at the Department of Energy's SLAC National Accelerator Laboratory, scientists precisely measured the temperature and structure of aluminum as...
The IPH presents a solution at HANNOVER MESSE 2015 to make ship traffic more reliable while decreasing the maintenance costs at the same time. In cooperation with project partners, the research institute from Hannover, Germany, has developed a sensor system which continuously monitors the condition of the marine gearbox, thus preventing breakdowns. Special feature: the monitoring system works wirelessly and energy-autonomously. The required electrical power is generated where it is needed – directly at the sensor.
As well as cars need to be certified regularly (in Germany by the TÜV – Technical Inspection Association), ships need to be inspected – if the powertrain stops...
When an earthquake hits, the faster first responders can get to an impacted area, the more likely infrastructure--and lives--can be saved.
The Atlantic overturning is one of Earth’s most important heat transport systems, pumping warm water northwards and cold water southwards. Also known as the Gulf Stream system, it is responsible for the mild climate in northwestern Europe.
Scientists now found evidence for a slowdown of the overturning – multiple lines of observation suggest that in recent decades, the current system has been...
Because they are regularly subjected to heavy vehicle traffic, emissions, moisture and salt, above- and underground parking garages, as well as bridges, frequently experience large areas of corrosion. Most inspection systems to date have only been capable of inspecting smaller surface areas.
From April 13 to April 17 at the Hannover Messe (hall 2, exhibit booth C16), engineers from the Fraunhofer Institute for Nondestructive Testing IZFP will be...
25.03.2015 | Event News
19.03.2015 | Event News
17.03.2015 | Event News
27.03.2015 | Agricultural and Forestry Science
27.03.2015 | Materials Sciences
27.03.2015 | Ecology, The Environment and Conservation