In the treatment of stroke, there is currently only a three-hour "window of therapeutic opportunity" to prevent additional brain cell damage and only one medication approved to improve blood flow to oxygen-deprived neurons near the injury, thereby minimizing potentially debilitating side effects.
Now, scientists from Northwestern University report that a single injection of a chemical they created -- given up to six hours after brain injury or stroke -- protects against additional brain cell death for a week or longer. An article describing the new compound and its activity in the body appears in the September online issue of the Bioorganic and Medicinal Chemistry Letters.
The compound inhibits activity of an enzyme called death-associated protein kinase (DAPK), known to be an early player in the chain of molecular events leading to apoptosis, or programmed cell death. Earlier studies showed that levels of DAPK increase markedly prior to neuron death and that apoptosis increases rapidly hours after the onset of a stroke in laboratory models.
Elizabeth Crown | EurekAlert!
Research reveals how diabetes in pregnancy affects baby's heart
13.12.2017 | University of California - Los Angeles Health Sciences
Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
11.12.2017 | Event News
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13.12.2017 | Health and Medicine