Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Putting the brakes on tumor growth

21.01.2015

Some types of cancer grow incredibly quickly. They have to employ tricks to acquire the nutrients they need for this from their environment. In the quest for new targets for treatment, these tricks are high on the agenda. An international team of scientists has now managed to shed light on crucial details.

Without the ACSS2 enzyme, cancer cells would scarcely be able to divide and multiply as rapidly as they sometimes do. This enzyme enables them to use acetate, in other words acetic acid ester, instead of glucose to produce lipids and thus erect new cell walls, for example. If the enzyme is missing, the cancer cells die under certain conditions.

This discovery is now being reported by an international team of scientists in the journal Cancer Cell. According to the scientists, this discovery may provide a suitable target for a new treatment in which the tumor is “starved”, so to speak. Würzburg professor Almut Schulze is involved in the work. She has been conducting research at the University of Würzburg’s Biocenter in the Department of Biochemistry and Molecular Biology for the past year; prior to that, she worked for 16 years at Cancer Research UK’s London Research Institute.

Effective strategies to combat the lack of nourishment

In contrast to normal cells in tissues, cancer cells multiply very quickly. To do this they need sufficient nourishment to construct new cell components and gain energy. An important nutrient for cancer cells is glucose, which the organism acquires by breaking down food and distributes throughout the body in the bloodstream. However, tumors often grow so quickly that they are not supplied with sufficient blood vessels. So, they lack nutrients and oxygen, which noticeably retards their growth. Cancer cells, however, have developed strategies that enable them to continue to grow even under these conditions. Researchers are trying to identify these changes in the metabolism of cancer cells so that they can use this knowledge to find new targets for cancer treatment.

Sights set on prominent enzymes

In the study just published in the journal Cancer Cell researchers from various disciplines came together to tackle this problem from numerous angles. “First of all we simulated the metabolic processes in cancer cells on the computer and then analyzed them,” reports Almut Schulze. The scientists focused mainly on enzymes that control particularly important responses. They actually discovered a large number of enzymes that are needed for the formation of lipids.

As a next step they deliberately deactivated individual enzymes in breast cancer and prostate carcinoma cells, with the help of genetic engineering, and examined the effects on the growth of the cells. To simulate the conditions in the tumor, the cells were held in a special incubator in which the concentration of oxygen could be regulated. The burning question here: Which enzyme needs to be deactivated in order for cancer cells in a low-oxygen environment to die?

“The enzyme that had the strongest effect was ACSS2,” Almut Schulze reveals. ACSS2 enables cancer cells to switch to acetate when they are lacking glucose and to continue producing lipids in that manner. Acetate is found in small quantities in the blood and in tissues and can be absorbed and processed by tumor cells under certain conditions. As the studies by the scientists show, cancer cells absorb increased acetate and use it to produce lipids if they lack oxygen.

Growth successfully retarded in the experiment

“When the ACSS2 enzyme was deactivated, the cells were no longer able to construct sufficient cell components. As a result, the cells could no longer multiply so quickly, and tumor growth in laboratory animals could be halted,” reveals Schulze. To show that ACSS2 also plays an important role in human tumors, the researchers also examined tissue in breast cancer patients. They found that extremely advanced and aggressive tumors that often contain regions with a shortage of oxygen form large quantities of this enzyme. “If we could develop an agent that stops ACSS2 from functioning, this could be used to treat such tumors,” hopes the scientist.

Experts from many places and numerous fields

Molecular biologists, biochemists and pharmaceutical chemists, each one an expert in his or her research area, from London, Cambridge, Oxford, Glasgow, and Würzburg, were involved in the study; they were supported by the staff of a large pharmaceutical company. The team led by Almut Schulze has been looking into the role of lipid synthesis in cancer development for many years now. Its main contribution to this study was its identification of ACSS2 as an important enzyme for the growth of cancer cells and its examination of tumor tissue. In future, Schulze and her colleagues are keen to investigate any further roles that ACSS2 might play for tumor cells.

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress. Zachary T. Schug, Barrie Peck, Dylan T. Jones, Qifeng Zhang, Shaun Grosskurth, Israt S. Alam, Louise M. Goodwin, Elizabeth Smethurst, Susan Mason, Karen Blyth, Lynn McGarry, Daniel James, Emma Shanks, Gabriela Kalna, Rebecca E. Saunders, Ming Jiang, Michael Howell, Francois Lassailly, May Zaw Thin, Bradley Spencer-Dene, Gordon Stamp, Niels J.F. van den Broek, Gillian Mackay, Vinay Bulusu, Jurre J. Kamphorst, Saverio Tardito, David Strachan, Adrian L. Harris, Eric O. Aboagye, Susan E. Critchlow, Michael J.O. Wakelam, Almut Schulze, and Eyal Gottlieb. http://dx.doi.org/10.1016/j.ccell.2014.12.002

Contact

Prof. Dr. Almut Schulze, T: +49 (0)931 31-83290, almut.schulze@uni-wuerzburg.de

Gunnar Bartsch | Julius-Maximilians-Universität Würzburg
Further information:
http://www.uni-wuerzburg.de

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

Im Focus: Optoelectronic Inline Measurement – Accurate to the Nanometer

Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.

New Manufacturing Technologies for New Products

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Hubble captures massive dead disk galaxy that challenges theories of galaxy evolution

22.06.2017 | Physics and Astronomy

New femto-camera with quadrillion fractions of a second resolution

22.06.2017 | Physics and Astronomy

Rice U. chemists create 3-D printed graphene foam

22.06.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>