Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Older patients recover more slowly from concussion


Older individuals may have a more difficult time recovering from concussion, according to a new study published online in the journal Radiology.

Older individuals may have a more difficult time recovering from concussion, according to a new study published online in the journal Radiology.

This image shows different working memory activation patterns in healthy control subjects and young and old patients with mild traumatic brain injury.

Credit: Radiological Society of North America

Mild traumatic brain injury (MTBI), or concussion, accounts for 75 percent of all TBI and represents an important public health problem. Difficulty in working memory is frequently reported in patients after concussion. However, neuropsychological tests, computed tomography (CT) and conventional magnetic resonance imaging (MRI) generally fail to reveal abnormal findings in these patients. Functional MRI (fMRI) has been increasingly used in assessing patients with MTBI.

"Old age has been recognized as an independent predictor of worse outcome from concussion, but most previous studies were performed on younger adults," said the study's lead author, David Yen-Ting Chen, M.D., from the Department of Radiology at Shuang-Ho Hospital, Taipei Medical University, in New Taipei City, Taiwan.

For this study, Dr. Chen and colleagues used fMRI to evaluate the effect of age on working memory performance and functional activation in the brain after MTBI. The researchers performed fMRI exams on 13 young adults (21-30 years old) and 13 older adults (51-68 years old) with MTBI and 26 age- and gender-matched controls. The first fMRI scan was performed within one month post-injury. A follow-up scan was performed six weeks after the first exam. The researchers then analyzed post-concussion symptoms, neuropsychological test results and working memory activity in both groups.

The analysis revealed that while performing working memory tasks, the young patients with concussion had initial activation that was greater than normal, known as hyperactivation, compared to young controls in the right precuneus and right inferior parietal gyrus of the brain, whereas the older patients had hypoactivation (less than normal) compared to older controls in the right precuneus and right inferior frontal gyrus.

In comparing the patients in initial and follow-up study, the young patients had significantly reduced post-concussion symptom score at follow-up than at the time of the initial exam, but no significant change of the post-concussion symptom score was observed in the older patients, who also showed persistent hypoactivation.

"Taken together, these findings provide evidence for differential neural plasticity across different ages, with potential prognostic and therapeutic implications," said the study's co-author, Ying-Chi Tseng, M.D., from Shuang-Ho Hospital. "The results suggest that MTBI might cause a more profound and lasting effect in older patients."

The researchers hope that these findings might eventually lead to the development of separate management strategies for different age groups following concussion.


"Effect of Age on Working Memory Performance and Cerebral Activation after Mild Traumatic Brain Injury: A Functional MR Imaging Study." Collaborating with Drs. Chen and Tseng on this paper were Hui-Ling Hsu, M.D., Ying-Sheng Kuo, M.D., Changwei Wesley Wu, Ph.D., Wen-Ta Chiu, M.D., Ph.D., Feng-Xian Yan, M.S., Wei-Shuan Wang, B.S., and Chi-Jen Chen, M.D.

Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc.

RSNA is an association of more than 54,000 radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (

For patient-friendly information on MRI of the brain, visit

Media Contact

Linda Brooks


Linda Brooks | EurekAlert!

Further reports about: MRI RSNA Radiological Society activation fMRI older patients working memory

More articles from Health and Medicine:

nachricht NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>