Blood clots in veins and arteries can lead to heart attack, stroke, and pulmonary embolism, which are major causes of mortality. In the featured article of The Journal of Nuclear Medicine's (JNM) July 2017 issue, German researchers show that targeting GPIIb/IIIa receptors, the key receptor involved in platelet clumping, with a fluorine-18 (18F) labeled ligand is a promising approach for diagnostic imaging. Current imaging modalities rely on structural characteristics, such as vascular flow impairment, and do not address the critical molecular components.
"Currently available diagnostic techniques of thrombus [blood clot] imaging rely on different modalities depending on the vascular territory," explains Andrew W. Stephens, MD, PhD, of Piramal Imaging GmbH, Berlin, Germany. "A single imaging modality that could visualize thrombi from various sources in different anatomic regions would be very valuable."
For this preclinical study, researchers successfully developed the novel small molecule tracer 18F-GP1 for positron emission tomography (PET) imaging that binds with high affinity to GPIIb/IIIa receptors. 18F-GP1 showed a strong accumulation at the site of thrombus formation, and its binding ability was not affected by anticoagulants such as aspirin and heparin. The tracer showed rapid blood clearance, and PET imaging in a Cynomolgus monkey model demonstrated the detection of small venous and arterial clots, endothelial damage and emboli in the brain.
Due to the favorable pre-clinical results, a first-in-human study of 18F-GP1 is currently underway. Early results from an interim analysis confirm the preclinical data and were presented at the 2017 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) in June.
"Although the current studies are preliminary, 18F-GP1 may provide not only more accurate anatomic localization, but also information of the risk of the clot growth or embolization," Stephens points out. "This may lead to changes in clinical intervention to the individual patient." Addressing the use of anticoagulants to treat blood clots, he notes, "These drugs can cause significant and life-threatening bleeding. There is a critical need to balance the risk of bleeding against the risk of clotting in each patient. 18F-GP1 may in the future assist in this important decision."
The authors of "18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi" include Jessica Lohrke, Holger Siebeneicher, Markus Berger, Michael Reinhardt, Marcus Bauser, and Joachim Huetter of Bayer AG, Drug Discovery, Berlin, Germany, and Mathias Berndt, Andre Mueller, Marion Zerna, Norman Koglin, Felix Oden, Matthias Friebe, Ludger M. Dinkelborg, and Andrew W. Stephens of Piramal Imaging GmbH, Berlin, Germany.
This study was funded by Bayer Pharma AG and Piramal Imaging GmbH, Berlin, Germany.
Please visit the SNMMI Media Center (http://www.
About the Society of Nuclear Medicine and Molecular Imaging
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and medical organization dedicated to raising public awareness about nuclear medicine and molecular imaging, a vital element of today's medical practice that adds an additional dimension to diagnosis, changing the way common and devastating diseases are understood and treated and helping provide patients with the best health care possible.
SNMMI's more than 17,000 members set the standard for molecular imaging and nuclear medicine practice by creating guidelines, sharing information through journals and meetings and leading advocacy on key issues that affect molecular imaging and therapy research and practice. For more information, visit http://www.
Laurie Callahan | EurekAlert!
'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS
New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
19.02.2018 | Materials Sciences
19.02.2018 | Materials Sciences
19.02.2018 | Life Sciences