Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New technique could prevent dangerous biofilms on catheters

17.11.2015

Biofilms frequently coat the surfaces of catheters, and of various medical implants and prostheses, where they can cause life-threatening infections. New research at the Sahlgrenska Academy show that coating implants with a certain ”activator” can prevent Staphylococcus aureus, the leading cause of hospital-acquired infections, from forming biofilms.

Biofilms are mats of bacteria similar to the plaque that grows on teeth. Biofilms frequently coat the surfaces of catheters, and of various medical implants and prostheses, where they can threaten lives or lead to failure of the implants.


Staphylococcus aureus bacteria forming biofilm - New technique could prevent dangerous biofilms on catheters

University of Gothenburg

Antibiotics are impotent against biofilms. Now Gothenburg researchers Jakub Kwiecinski, Tao Jin and collaborators show that coating implants with “tissue plasminogen activator” can prevent Staphylococcus aureus, the leading cause of hospital-acquired infections, from forming biofilms.

Hijacks the system

A growing biofilm requires anchoring, and in earlier research, this team, led by Jin, an Associate Professor of Rheumatology and Inflammation Research, the University of Gothenburg, Gothenburg, Sweden, had discovered that S. aureus hijacks the human clotting system to create a scaffold of micro-clots to support the growing biofilm.

“We hypothesized that if we forced the human body to start dissolving those clots, we could prevent the biofilm from developing,” said Kwiecinski, a post-doctoral researcher in Jin’s laboratory.

Clot-dissolving protein

To encouraging the clot-busting, the investigators coated the surfaces with tissue plasminogen activator (tPA), which activates the clot-dissolving protein, plasminogen.

“This deprives S. aureus of a scaffold for biofilm formation and prevents infection,” said Kwiecinski. After performing the research under laboratory conditions, they confirmed that it works by coating catheters that they then implanted into laboratory mice.

Looking beyond bacteria

A key to the team’s success was their decision to look beyond the bacteria, the stopping place for most previous research, to the human body’s involvement in the infections, said Kwiecinski. The clot-busting, he said, could be applied to biofilms of pathogens other than S. aureus.

Biofilm-related infections afflict around 1.7 million in the US alone, killing nearly 100,000 annually, according to the Center for Disease Control and Prevention. “With increasing numbers of prosthetic devices used in modern medicine, this number is only going to increase,” said Kwiecinski. Thus, the research could lead to a major reduction in hospital-acquired disease and death.

The article Tissue plasminogen activator coating on implant surfaces reduces Staphylococcus aureus biofilm formation was published online in Applied and Environmental Microbiology.

Link to article: http://aem.asm.org/cgi/reprint/AEM.02803-15v1?ijkey=jEqeGWGNE/hZk&keytype=re...

For more information please contact:
Tao Jin, Associate Professor at the Sahlgrenska Academy, University of Gothenburg
+4631-3429710
tao.jin@rheuma.gu.se

Jakub Kwiecinski, postdoc at The University of Iowa, USA, former PhD-student at the Sahlgrenska Academy, University of Gothenburg
jakub.kwiecinski@rheuma.gu.se

Weitere Informationen:

http://sahlgrenska.gu.se/english/research/news-article/?languageId=100001&co...

Calle Björned | idw - Informationsdienst Wissenschaft

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>