Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


New role for immune cells in preventing diabetes and hypertension


Immune cells which are reduced in number by obesity could be a new target to treat diseases such as type 2 diabetes and hypertension that affect overweight people, according to a collaborative study between The University of Manchester, Lund University and the University of Salford.

In a study published in the journal Scientific Reports, the researchers from immunology and cardiovascular backgrounds investigated a type of immune cell called eosinophils. Eosinophils are present in a layer of fat tissue called the perivascular adipose tissue (PVAT), which surrounds blood vessels and helps to maintain normal blood vessel function by reducing artery contraction.

Immune cells which are reduced in number by obesity could be a new target to treat diseases such as type 2 diabetes and hypertension that affect overweight people, according to a collaborative study between the University of Manchester, Lund University and the University of Salford.

Credit: The University of Manchester

The current research by the researchers found that eosinophils were considerably reduced in the PVAT in obesity in mice, and that the PVAT function was severely impaired, contributing to type 2 diabetes and hypertension. This is not something that has previously been observed.

Dr Sheena Cruickshank, the lead researcher on the Wellcome Trust-funded study, said: "This type of immune cell is present in many parts of the body and was once thought to just act in parasitic infections and allergies, but it's fast becoming clear that they have a significant effect on lots of aspects of health and immunity".

"Our study showed that in fact the secretions from eosinophils have a profound effect on how the blood vessels operate and when they are missing, as in obesity, serious health problems can start to develop."

The role of the eosinophils also opens up new opportunities to investigate treatments for type 2 diabetes and hypertension.

PVAT from fat that lack eosinophils could quickly be rescued by addition of eosinophils, demonstrating that there is the potential for a treatment based on restoring this function.

The researchers observed that the eosinophils influenced the release of nitric oxide and a protein called adiponectin, which control healthy PVAT function. This appears to be a unique function of these immune cells. The researchers are particularly excited by how quickly the eosinophils could restore PVAT function, showing just how potent they may be.

Dr Cruickshank added: "These immune cells have been traditionally overlooked but this study shows for the first time that they have a direct role to play in processes in the body beyond the immune system.

"They seem to be incredibly important in a number of processes and this presents us with an exciting new area to investigate for a whole range of illnesses."

The paper 'Eosinophils are key regulators of perivascular adipose tissue and vascular functionality' will be published in Scientific Reports.

Media Contact

Jamie Brown


Jamie Brown | EurekAlert!

More articles from Health and Medicine:

nachricht NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Tiny implants for cells are functional in vivo

For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.

In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

Latest News

Earlier flowering of modern winter wheat cultivars

20.03.2018 | Agricultural and Forestry Science

Smithsonian researchers name new ocean zone: The rariphotic

20.03.2018 | Life Sciences

Molecular doorstop could be key to new tuberculosis drugs

20.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>