Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Lung cancer may be treatable with use of SapC-DOPS technology, research shows

10.02.2015

Lung cancer is the most common and the deadliest type of cancer worldwide, with about 221,000 new cases and an estimated 158,000 deaths in 2015 in the U.S., according to the American Cancer Society.

Cigarette smoking is the leading cause of lung cancer, followed by environmental and occupational exposure to pollutants.

A University of Cincinnati (UC) study, published in the advance online edition of the journal Molecular Cancer Therapeutics, provides hope that the therapeutic agent SapC-DOPS could be used for treatment of this cancer.

Xiaoyang Qi, PhD, associate director and associate professor in the Division of Hematology Oncology at the UC College of Medicine and a member of the Cincinnati Cancer Center, the UC Cancer and Neuroscience Institutes and the Brain Tumor Center, says these findings indicate that SapC-DOPS shows promise for treatment of one of the deadliest cancers globally. The findings also provide stronger evidence that this agent could be a key treatment for a variety of cancers.

"I partnered with scientists at Nanjing Medical University in China for this research, as lung cancer in China is a major health issue," Qi says. "As reported by the International Agency for Research on Cancer, more than half of lung cancer deaths caused by air pollutants worldwide occurred in China and other East Asian countries.

"Standard treatment options for lung cancer, including chemotherapy, radiation and surgery, have undesirable side effects that impact the quality of life of the cancer patient, which is why the targeted use of SapC-DOPS could be so beneficial."

SapC-DOPS consists of a lysosomal protein, saposin C (SapC), and a phospholipid named dioleoylphosphatidylserine (DOPS), which are combined and assembled into tiny cavities, or nanovesicles, to target and kill various forms of cancer cells.

Lysosomes are membrane-enclosed organelles that contain enzymes capable of breaking down all types of biological components; phospholipids are major components of all cell membranes and form lipid bilayers--or cell membranes.

Qi and collaborators have previously found that the combination of these two natural cellular components, called SapC-DOPS, caused cell death in many cancer cell types including brain, skin, prostate, blood, breast and pancreatic cancer, while sparing normal cells and tissues.

"Liposomal formulations as vehicles for drug delivery are the subject of intense research," he continues. "Compared with non-encapsulated, free drugs, they provide improved biocompatibility and targeted delivery. Despite promising results in preclinical models of lung cancer and many other cancer types, only a few non-targeted liposomal formulations have been approved for cancer treatment by regulatory agencies. Clinical trials are under way to evaluate some of these in lung cancer patients. However, so far, these liposomes have been shown to be less effective when compared with free drug administration, which is why the SapC-DOPS research is promising as a targeted treatment for lung cancer."

In this study, researchers used SapC-DOPS to selectively target the cell membrane of lung tumors in animal models and in human cell cultures.

Qi says a distinguishing feature of SapC-DOPS is its ability to bind to phosphatidylseriine (PS), a lipid, which is found on the membrane surfaces of all tumor cells.

"To evaluate the role of external cell PS, we evaluated PS exposure in human tumor and non-tumor cells in culture," he says. "We also introduced these cells into animal models and then injected the SapC-DOPS vesicles intravenously to see if we could halt tumor growth."

"Using a double-tracking method in live models, we showed that the nanovesicles were specifically targeted to the tumors. These data suggest that the acidic phospholipid PS is a biomarker for lung cancer, as it has been found to be for pancreatic and brain tumors in previous studies, and can be effectively targeted for therapy using cancer-selective SapC-DOPS nanovesicles."

"We observed that the nanovesicles selectively killed human lung cancer cells, and the noncancerous, or untransformed cells, remained unaffected," Qi continues. "This toxic effect correlated to the surface exposure level of PS on the tumor cells."

Importantly, animals treated with SapC-DOPS showed clear survival benefits and their tumors shrank or disappeared.

"Our results show that SapC-DOPS could be a promising treatment option for lung cancer worthy of further clinical study."

###

Other collaborators on this study include Shuli Zhao, Yunzhong Nie and Yayi Hou, all affiliated with Nanjing Medical University; Zhengtao Chu, UC and Cincinnati Children's Hospital Medical Center; and Victor Blanco, UC.

This work was supported in part by the National Institutes of Health/National Cancer Institute (1R01CA158372), the New Drug State Key Project (009ZX09102-20) and the Division of Hematology Oncology, University of Cincinnati College of Medicine.

The development and commercialization of this technology has been licensed to Bexion Pharmaceuticals, LLC, in which Qi, holds a minor (less than 5 percent) equity interest. The other authors declared no conflict of interest.

Media Contact

Katie Pence
katie.pence@uc.edu
513-558-4561

 @UCHealthNews

http://www.healthnews.uc.edu 

Katie Pence | EurekAlert!

More articles from Health and Medicine:

nachricht Finnish research group discovers a new immune system regulator
23.02.2018 | University of Turku

nachricht Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Attoseconds break into atomic interior

A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.

In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...

Im Focus: Good vibrations feel the force

A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.

By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Basque researchers turn light upside down

23.02.2018 | Physics and Astronomy

Finnish research group discovers a new immune system regulator

23.02.2018 | Health and Medicine

Attoseconds break into atomic interior

23.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>