Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

14.09.2017

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.


Multi-well tissue plate (48-well format) for automated cardiotoxic or drug screening. In each well a fully functional heart muscle tissue ring has been produced around two flexible pins, which can be easily monitored by automated video analysis. Source: T. Meyer.

This lab innovation is based on previous scientific work from the group of Prof. Dr. Wolfram-Hubertus Zimmermann, Director of the Institute for Pharmacology and Toxicology at the UMG. Under the terms of the non-exclusive license agreement UMG will receive an upfront payment and, besides royalties, annual minimum license fees.

Unwanted side effects affecting the heart are among the most common causes for the high attrition rate in drug development. Furthermore, cardiovascular diseases are the major cause of death in Germany, accounting for almost 40% of the annual mortalities. Hence, preclinical testing for both cardiac toxicity as well as drug efficacy is an important precondition for successful drug development. Currently, these tests are primarily performed in cell cultures or animal models.

Because these models do not accurately reflect human physiology, there is a concern of limited predictive value as to clinical relevance of the obtained knowledge. Instead, tissue-engineered and lab-grown human tissues can much better reflect physiological conditions.

The newly developed multi-well tissue plate at UMG (currently at a 48-well format) allows for a standardized generation of human heart muscle under defined conditions from stem cells in a simple one-step procedure. The culture format was designed to be ready for automation and analytic monitoring of tissue function without manual handling - enabling effective high-throughput drug testing. The platform can be easily adapted for use with other tissue formats.

Tissue Systems Holding GmbH is a biotech company founded in 2012, which owns and commercializes technologies in the field of tissue engineering particularly in cardiology. The daughter company Myriamed GmbH (www.myriamed.com) is the operative arm and commercializes these technologies as a service provider for drug and toxicity screenings.

University Medical Center Göttingen (UMG) brings together the Medical Faculty and the University Clinic under one roof. It focuses on research on socially important diseases. These research areas are intended to provide a transfer from basic research to clinical practice.

The UMG is the only maximum care hospital in southern Lower Saxony and is involved in three clinical and research areas: neurosciences, cardiovascular diseases and oncology. Since 2003 UMG and University of Göttingen have been University of Göttingen public law foundation. The UMG is also the largest employer in the region in southern Lower Saxony.

MBM ScienceBridge GmbH is a fully owned technology transfer organization by the University of Göttingen and acts on behalf of nine research institutions in Lower Saxony as a technology transfer interface to companies around the world. The IP portfolio managed by MBM ScienceBridge covers innovation in the areas of Life Sciences, Chemistry, Physics, Agriculture, Forestry and Medical Technologies.

photo: Multi-well tissue plate (48-well format) for automated cardiotoxic or drug screening. In each well a fully functional heart muscle tissue ring has been produced around two flexible pins, which can be easily monitored by automated video analysis. Source: T. Meyer.

contact: www.sciencebridge.de, info@sciencebridge.de, +49-(0)551-30724151.

Stefan Weller | idw - Informationsdienst Wissenschaft
Further information:
http://www.universitaetsmedizin-goettingen.de/

More articles from Health and Medicine:

nachricht Dengue takes low and slow approach to replication
12.01.2018 | Duke University

nachricht Fast food makes the immune system more aggressive in the long term
12.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

Im Focus: Autoimmune Reaction Successfully Halted in Early Stage Islet Autoimmunity

Scientists at Helmholtz Zentrum München have discovered a mechanism that amplifies the autoimmune reaction in an early stage of pancreatic islet autoimmunity prior to the progression to clinical type 1 diabetes. If the researchers blocked the corresponding molecules, the immune system was significantly less active. The study was conducted under the auspices of the German Center for Diabetes Research (DZD) and was published in the journal ‘Science Translational Medicine’.

Type 1 diabetes is the most common metabolic disease in childhood and adolescence. In this disease, the body's own immune system attacks and destroys the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fachtagung analytica conference 2018

15.01.2018 | Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

 
Latest News

Black hole spin cranks-up radio volume

15.01.2018 | Physics and Astronomy

A matter of mobility: multidisciplinary paper suggests new strategy for drug discovery

15.01.2018 | Life Sciences

New method to map miniature brain circuits

15.01.2018 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>