Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

14.09.2017

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.


Multi-well tissue plate (48-well format) for automated cardiotoxic or drug screening. In each well a fully functional heart muscle tissue ring has been produced around two flexible pins, which can be easily monitored by automated video analysis. Source: T. Meyer.

This lab innovation is based on previous scientific work from the group of Prof. Dr. Wolfram-Hubertus Zimmermann, Director of the Institute for Pharmacology and Toxicology at the UMG. Under the terms of the non-exclusive license agreement UMG will receive an upfront payment and, besides royalties, annual minimum license fees.

Unwanted side effects affecting the heart are among the most common causes for the high attrition rate in drug development. Furthermore, cardiovascular diseases are the major cause of death in Germany, accounting for almost 40% of the annual mortalities. Hence, preclinical testing for both cardiac toxicity as well as drug efficacy is an important precondition for successful drug development. Currently, these tests are primarily performed in cell cultures or animal models.

Because these models do not accurately reflect human physiology, there is a concern of limited predictive value as to clinical relevance of the obtained knowledge. Instead, tissue-engineered and lab-grown human tissues can much better reflect physiological conditions.

The newly developed multi-well tissue plate at UMG (currently at a 48-well format) allows for a standardized generation of human heart muscle under defined conditions from stem cells in a simple one-step procedure. The culture format was designed to be ready for automation and analytic monitoring of tissue function without manual handling - enabling effective high-throughput drug testing. The platform can be easily adapted for use with other tissue formats.

Tissue Systems Holding GmbH is a biotech company founded in 2012, which owns and commercializes technologies in the field of tissue engineering particularly in cardiology. The daughter company Myriamed GmbH (www.myriamed.com) is the operative arm and commercializes these technologies as a service provider for drug and toxicity screenings.

University Medical Center Göttingen (UMG) brings together the Medical Faculty and the University Clinic under one roof. It focuses on research on socially important diseases. These research areas are intended to provide a transfer from basic research to clinical practice.

The UMG is the only maximum care hospital in southern Lower Saxony and is involved in three clinical and research areas: neurosciences, cardiovascular diseases and oncology. Since 2003 UMG and University of Göttingen have been University of Göttingen public law foundation. The UMG is also the largest employer in the region in southern Lower Saxony.

MBM ScienceBridge GmbH is a fully owned technology transfer organization by the University of Göttingen and acts on behalf of nine research institutions in Lower Saxony as a technology transfer interface to companies around the world. The IP portfolio managed by MBM ScienceBridge covers innovation in the areas of Life Sciences, Chemistry, Physics, Agriculture, Forestry and Medical Technologies.

photo: Multi-well tissue plate (48-well format) for automated cardiotoxic or drug screening. In each well a fully functional heart muscle tissue ring has been produced around two flexible pins, which can be easily monitored by automated video analysis. Source: T. Meyer.

contact: www.sciencebridge.de, info@sciencebridge.de, +49-(0)551-30724151.

Stefan Weller | idw - Informationsdienst Wissenschaft
Further information:
http://www.universitaetsmedizin-goettingen.de/

More articles from Health and Medicine:

nachricht Asthma drug from the garden center
14.09.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht How Liver Cancer Develops
12.09.2017 | Universität Zürich

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

Im Focus: Silencing bacteria

HZI researchers pave the way for new agents that render hospital pathogens mute

Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...

Im Focus: Artificial Enzymes for Hydrogen Conversion

Scientists from the MPI for Chemical Energy Conversion report in the first issue of the new journal JOULE.

Cell Press has just released the first issue of Joule, a new journal dedicated to sustainable energy research. In this issue James Birrell, Olaf Rüdiger,...

Im Focus: Using Mirrors to Improve the Quality of Light Particles

Scientists from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute have succeeded in dramatically improving the quality of individual photons generated by a quantum system. The scientists have successfully put a 10-year-old theoretical prediction into practice. With their paper, published recently in Physical Review X, they have taken an important step towards future applications in quantum information technology.

For a number of years, scientists have been working on using electron spins to store and process information. A possible approach is to use a quantum system in...

Im Focus: High-speed Quantum Memory for Photons

Physicists from the University of Basel have developed a memory that can store photons. These quantum particles travel at the speed of light and are thus suitable for high-speed data transfer. The researchers were able to store them in an atomic vapor and read them out again later without altering their quantum mechanical properties too much. This memory technology is simple and fast and it could find application in a future quantum Internet. The journal Physical Review Letters has published the results.

Even today, fast data transfer in telecommunication networks employs short light pulses. Ultra broadband technology uses optical fiber links through which...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

IVAM’s LaserForum visits the Swiss canton of St. Gallen with the topic ultrashort pulse lasers

06.09.2017 | Event News

 
Latest News

Asthma drug from the garden center

14.09.2017 | Health and Medicine

New Inhibitor Brings New Hope

14.09.2017 | Life Sciences

Study of transplanted hearts reveals risk gene for cardiovascular disease

14.09.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>