Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Brain cells that control appetite identified for first time

28.09.2017

Dieting could be revolutionized, thanks to the groundbreaking discovery by the University of Warwick of the key brain cells which control our appetite

  • Key brain cells which control our appetite discovered by scientists at University of Warwick
  • Tanycytes found - for the first time - to detect amino acids from food and tell the brain directly that we feel full
  • Foods high in two key amino acids - such as pork shoulder, beef sirloin steak, chicken, mackerel, plums, apricots, avocadoes, lentils and almonds - activate tanycytes and make us feel fuller quicker
  • Discovery could help to curb obesity crisis - possibility of treatments to suppress appetite and control weight by activating tanycytes in brain

Tanycyte cells reacting to a puff of the amino acid arginine.

Credit: Professor Nicholas Dale/Ms. Greta Lazutkaite

Dieting could be revolutionised, thanks to the ground-breaking discovery by the University of Warwick of the key brain cells which control our appetite.

Professor Nicholas Dale in the School of Life Sciences has identified for the first time that tanycytes - cells found in part of the brain that controls energy levels - detect nutrients in food and tell the brain directly about the food we have eaten.

... more about:
»acids »amino acids »brain cells »lysine

According to the new research, tanycytes in the brain respond to amino acids found in foods, via the same receptors that sense the flavour of amino acids ("umami" taste), which are found in the taste buds of the tongue.

Two amino acids that react most with tanycytes - and therefore are likely to make you feel fuller - are arginine and lysine.

These amino acids are found in high concentration in foods such as pork shoulder, beef sirloin steak, chicken, mackerel, plums, apricots, avocadoes, lentils and almonds - so eating those foods will activate the tanycytes and make you feel less hungry quicker.

The researchers made their discovery by adding concentrated amounts of arginine and lysine into brain cells, which were made fluorescent so that any microscopic reactions would be visible. They observed that within thirty seconds, the tanycytes detected and responded to the amino acids, releasing information to the part of the brain that controls appetite and body weight.

They found that signals from amino acids are directly detected by the umami taste receptors by removing or blocking these receptors and observing that the amino acids no longer reacted with tanycytes.

Nicholas Dale, who is Ted Pridgeon Professor of Neuroscience at the University of Warwick, commented:

"Amino acid levels in blood and brain following a meal are a very important signal that imparts the sensation of feeling full. Finding that tanycytes, located at the centre of the brain region that controls body weight, directly sense amino acids has very significant implications for coming up with new ways to help people to control their body weight within healthy bounds."

This major discovery opens up new possibilities for creating more effective diets - and even future treatments to suppress one's appetite by directly activating the brain's tanycytes, bypassing food and the digestive system.

Nearly two thirds of the UK population is overweight or obese. This excess weight elevates the risk of premature death and a range of illnesses, such as cancer, diabetes, cardiovascular disease and stroke, which greatly reduce quality of life. A new understanding of how appetite functions could curb the growing obesity crisis.

The research, 'Amino Acid Sensing in Hypothalamic Tanycytes via Umami Taste Receptors', will be published in Molecular Metabolism.

It is funded by the Biotechnology and Biological Sciences Research Council.

Media Contact

Luke Walton
L.Walton.1@warwick.ac.uk
44-078-245-40863

 @warwicknewsroom

http://www.warwick.ac.uk 

Luke Walton | EurekAlert!

Further reports about: acids amino acids brain cells lysine

More articles from Health and Medicine:

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Previous evidence of water on mars now identified as grainflows

21.11.2017 | Physics and Astronomy

NASA's James Webb Space Telescope completes final cryogenic testing

21.11.2017 | Physics and Astronomy

New catalyst controls activation of a carbon-hydrogen bond

21.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>