Researchers at Tokyo Medical and Dental University (TMDU) show that an analyzer recently developed to measure blood coagulability has the sensitivity to detect hypercoagulatibility associated with stroke risk in those without atrial fibrillation
Atrial fibrillation (AF) causes an irregular and sometimes fast heart rate, and is a common risk factor for stroke. To estimate this risk in AF patients and determine the requirement for anticoagulation therapy, the CHADS2 predictive score is used.
Because some parts of this score are also associated with atherosclerosis risk and increased blood coagulability, a high score has been proposed as linked to hypercoagulability (an increased tendency for blood clotting) in both AF and non-AF patients. However, this association has not been fully investigated, partly owing to the lack of a sensitive means of detection.
A research team from TMDU used a highly sensitive technique to measure small changes in blood coagulation, and found hypercoagulability in non-AF patients with high CHADS2 scores. The study was recently reported in PLOS ONE.
Several physical and chemical factors affect blood clotting, some of which can be measured over time to determine blood coagulability and the likelihood of clot formation. Dielectric blood coagulometry (DBCM) is a recently developed test that measures changes in the dielectric permittivity of whole blood, representing clumping of red blood cells.
The researchers used DBCM to detect changes in the dielectric permittivity of whole blood at 10 MHz. Comparisons between untreated blood and that with added heparin (a blood thinner) or tissue factor (a blood-clotting accelerator) enabled derivation of a coagulability index.
"We calculated the end of acceleration time (EAT) as an index of coagulability from temporal changes in dielectric permittivity," coauthor Satomi Hamada says. "This value reduced when tissue factor was added, and increased with heparin present. It was also sensitive enough to detect small changes in coagulability, particularly in hypercoagulability." EAT also boasts high reproducibility and reliability.
The researchers found that patients receiving warfarin had a significantly longer EAT than those without, confirming the anticoagulation effect. They also showed that patients with a high CHADS2 score had a significantly shorter EAT that represented hypercoagulability compared with patients with lower CHADS2 scores. "Intriguingly, EAT varied widely in patients with CHADS2 scores of 0 or 1," lead author Yuki Hasegawa says. "This suggests that DBCM can identify high risk of thrombosis even in patients with low CHADS2 scores."
The article, "Novel dielectric coagulometer identifies hypercoagulability in patients with a high CHADS2 score without atrial fibrillation" was published in PLOS ONE at DOI:10.1371/journal.pone.0156557
Tetsuta Sasano | EurekAlert!
New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia
New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).
The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
16.08.2017 | Physics and Astronomy
16.08.2017 | Materials Sciences
16.08.2017 | Interdisciplinary Research