Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

ARTORG and Inselspital develop artificial pancreas

26.11.2015

Artificial pancreas devices so far cannot compensate the daily varying food intake or physical activities of diabetes patients. The University of Bern, the Bern University Hospital and an industry partner have therefore set out to develop a more flexible device to continuously control patients’ blood sugar.

"Today, a diabetic patient must follow a very constraining therapy with many blood glucose measurements, dose calculations and insulin injections. The ideal would be to have a single system that can conduct all of these operations without requiring any intervention", says Prof. Peter Diem, Chairman and Head of the Department of Endocrinology, Diabetes and Clinical Nutrition at Inselspital.

Such a system needs to continuously measure and calculate the level of glucose present in the blood and to constantly deliver insulin via an infusion pump. The amount of infused insulin is determined by an algorithm that estimates the patient needs based on the measured glucose levels, the time of day or the expected activities and that will adapt the pump infusion rate accordingly.

Insulin need depends on daily activity and food profile

"Approaches taken so far do not resolve fundamental difficulties: the patients' variability, uncertainties related to system disturbances, e.g. food intake and physical activity, and errors related to the used devices,” says Dr. Stavroula Mougiakakou, Head of the Diabetes Technology Research Group at the University of Bern’s ARTORG Center.

“The proposed algorithm is easy to use, introduces the concept of real-time personalisation based on reinforcement learning, is able to tackle inter- and intra-patient variability, and can compensate for the effects of uncertain events."

Artificial pancreas has to work accurately and flexibly

The new artificial pancreas ARTORG and Inselspital wish to develop will include an infusion pump produced by an industry partner and an algorithm to run on a wireless PDA device used for the programming of the pump. The accuracy of the different elements in an artificial pancreas is critical.

The insulin levels have to be maintained in a very narrow window. Too little insulin will lead to hyperglycaemia, while too much insulin generates hypoglycaemia. Both situations may induce coma and even patient death. The proposed pump therefore emphasizes on accuracy and flexibility.

The patch pump will be directly placed on the skin, to continuously monitor therapy. It can be detached and reattached at will. A prototype of the pump has been tested by patients in a first clinical trial. After development and integration, the new control algorithm for the personalised delivery of insulin will be verified in a number of clinical trials.

"We are looking forward to seeing this new approach being used by patients and appreciate how much this may facilitate their treatment. It is even more important to improve their quality of life", says Prof. Christoph Stettler, newly elected Director of the Division of Endocrinology, Diabetes and Clinical Nutrition at Inselspital.

Further information:

On diabetes therapy:
Prof. Dr.med. Peter Diem, Chairman and Head, Division of Endocrinology, Diabetes and Clinical Nutrition, Inselspital, Bern University Hospital, +41 31 632 4070, peter.diem@insel.ch.

On the algorithm:
PD Dr. Stavroula Mougiakakou, ARTORG Center - Diabetes Technology Research, +41 31 632 75 92, stavroula.mougiakakou@artorg.unibe.ch.

On the infusion pump:
Laurent-Dominique Piveteau, Press Contacts, Debiotech SA, +41 21 623 60 00, ld.piveteau@debiotech.com.

Weitere Informationen:

http://www.insel.ch/en/

Monika Kugemann | Universitätsspital Bern

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>