Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

An immune system marker for therapy-resistant prostate cancer

05.06.2015

Interleukin-6 signaling plays role in switching mouse prostate cancer to more aggressive, therapy-resistant form

You are a patient who has just been treated for a serious illness but neither you nor your doctor knows how likely it is that you -- in comparison with other patients -- will actually be helped by the treatment. This is often the situation with prostate cancer, one of the deadliest and most highly prevalent cancers. While hormone therapy can help, patient responses vary widely, and it's still unclear why some types of prostate cancer seem to be resistant to the therapy.


In RApidCaP, a mouse model of human metastatic prostate cancer that they developed, Trotman and colleagues have identified an immune system marker that may help to distinguish patients who will and will not respond to hormone therapy. That marker is IL-6, an immune system component whose presence is indicated in brown patches in the image at left, in a section of lung tissue (blue) colonized by prostate cancer cells. The middle image of the same section of lung tissue indicates activation of STAT3, a protein that is the downstream target of IL-6 signaling. The image at right of the same tissue section demonstrates the presence of PCNA in the invading prostate cells, a marker of metastasis.

Courtesy of Trotman Lab/ CSHL

In work published today in Cancer Discovery, a team led by associate professor Lloyd Trotman at Cold Spring Harbor Laboratory (CSHL) shows how signaling by an immune system component called interleukin-6 (IL-6) appears to play an important role in driving particularly aggressive and therapy-resistant prostate cancer.

Our research suggests that IL-6 could be a marker for when the disease switches to a more dangerous state that is ultimately hormone therapy-resistant,' says Trotman.

The results could have important implications for human prostate cancer. 'The gain could be immense, because today's problem is that the variability in response of humans to hormone therapy is amazing,' Trotman says. 'For one man this therapy might be great, might reduce disease burden dramatically for many, many, years, and be an extreme benefit,' he says. 'For others there's almost no response, and it's still not clear to clinicians who is who.'

Being able to predict which patients would benefit from hormone therapy 'would be amazing,' Trotman says. 'We are really hopeful that translating the IL-6 discovery into the clinics could help us stratify patients into good responders and bad responders. For any hospital this would be a major breakthrough.'

Trotman and his team, which included Dawid Nowak, Ph.D., a postdoctoral investigator who is the paper's first author, looked for cellular signals that led to metastasis and hormone therapy resistance in a genetically engineered mouse model for metastatic prostate cancer. They found that the combined loss of two genes, PTEN and p53 -- closely associated with prostate cancer metastasis -- led to the secretion of IL-6. Signaling by IL-6 was then responsible for activating a powerful cancer gene called MYC, which drives cell proliferation and disease progression.

'It suggested immediately that cell-cell communication is very, very important to make the cells resistant to therapy and very aggressive,' says Trotman.

The involvement of the MYC pathway suggests that it could potentially serve as a target of drugs against prostate cancer, Trotman says. The team's next step is to study IL-6 signaling in humans. 'IL-6 detection in blood has been developed to a high art,' Trotman says. 'There are very good tools, which have been tested in the hospital setting.'

###

The work described in this release was supported by the Pershing Square Sohn Cancer Research Alliance; the American Cancer Society; the National Institutes of Health (CA137050); the Department of Defense (W81XWH-14-1-0247), the STARR Foundation (I8-A8-112), the Robertson Research Fund of CSHL; and the CSHL Cancer Center (through NIH Support Grant 5P30CA045508).

'MYC drives pten/Trp53-deficient proliferation and metastasis due to IL6 secretion and AKT suppression via PHLPP2' appeared online in Cancer Discovery June 3, 2015. The authors are: Dawid G. Nowak, Hyejin Cho, Tali Herzka, Kaitlin Watrud, Daniel V. DeMarco, Victoria M.Y. Wang, Serif Senturk, Christof Fellmann, David Ding, Tumas Beinortas, David Kleinman, Muhan Chen, Raffaella Sordella, John E. Wilkinson, Mireia Castillo-Martin, Carlos Cordon-Cardo, Brian D. Robinson, and Lloyd C. Trotman. The paper can be obtained online at: http://cancerdiscovery.aacrjournals.org/

About Cold Spring Harbor Laboratory

Celebrating its 125th anniversary in 2015, Cold Spring Harbor Laboratory has shaped contemporary biomedical research and education with programs in cancer, neuroscience, plant biology and quantitative biology. Home to eight Nobel Prize winners, the private, not-for-profit Laboratory is more than 600 researchers and technicians strong. The Meetings and Courses Program hosts more than 12,000 scientists from around the world each year on its campuses in Long Island and in Suzhou, China. The Laboratory's education arm also includes an academic publishing house, a graduate school and programs for middle and high school students and teachers. For more information, visit http://www.cshl.edu

Media Contact

Peter Tarr
tarr@cshl.edu
516-367-8455

 @CSHLnews

http://www.cshl.edu 

Peter Tarr | EurekAlert!

More articles from Health and Medicine:

nachricht How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego

nachricht Camouflage apples
22.03.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Pulverizing electronic waste is green, clean -- and cold

22.03.2017 | Materials Sciences

Astronomers hazard a ride in a 'drifting carousel' to understand pulsating stars

22.03.2017 | Physics and Astronomy

New gel-like coating beefs up the performance of lithium-sulfur batteries

22.03.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>