Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A tool to better screen and treat aneurysm patients

30.05.2014

New research by an international consortium, including a researcher from Lawrence Livermore National Laboratory, may help physicians better understand the chronological development of a brain aneurysm.

Using radiocarbon dating to date samples of ruptured and unruptured cerebral aneurysm (CA) tissue, the team, led by neurosurgeon Nima Etminan, found that the main structural constituent and protein -- collagen type I -- in cerebral aneurysms is distinctly younger than once thought.


A cerebral aneurysm is a blood-filled bulge formed in response to a weakness in the wall at branching brain arteries. If the bulge bursts (shown left), the person can undergo a brain hemorrhage, which is a subtype of stroke and a life-threatening condition. An international team including a researcher from Lawrence Livermore found that the main structural constituent and protein in cerebral aneurysms is distinctly younger than once thought. The new research helps identify patients more likely to suffer from an aneurysm and embark on a path toward prevention.

The new research helps identify patients more likely to suffer from an aneurysm and embark on a path toward prevention.

Simplified, a CA is a blood-filled bulge formed in response to a weakness in the wall at branching brain arteries. If the bulge bursts, the person can undergo a brain hemorrhage, which is a subtype of stroke and a life-threatening condition.

For decades, doctors have assumed that CAs rarely undergo structural change, and earlier theories speculated that CAs grow at a constant rate. The new findings, which appear in the June print issue of the journal Stroke, challenge the concept that CAs are present for decades and that they undergo only sporadic episodes of structural change. In view of these findings, it seems more likely that they alternate between periods of stability and instability during which they are prone to rupture.

For patients with CAs, who are more likely to undergo an aneurysm rupture due to risk factors such as smoking or hypertension, the international team including LLNL's Bruce Buchholz found that the age of collagen type I was significantly younger than those samples taken from people with no risk factors.

The ample amount of relatively young collagen type I in CAs suggests that collagen is changing all the time in aneurysms, which is significantly more rapid in patients with risk factors, Buchholz said.

Radiocarbon bomb-pulse dating uses an isotopic signature created by above-ground nuclear testing between 1955 and 1963, which nearly doubled the amount of carbon-14 in the atmosphere.

When the above-ground test-ban treaty took effect in 1963, atmospheric levels of radiocarbon began to decline as carbon-14 migrated into the oceans and biosphere. Living organisms naturally incorporate carbon into their tissues as the element moves through the food chain. As a result, the concentration of carbon-14 leaves a permanent time stamp on every biological molecule.

"This research may help doctors to formulate better screening and identification of those people at increased risk of an aneurysm rupture," Buchholz said.

The prevalence of unruptured CAs in the general population is 2 percent to 3 percent. The rate of death when they rupture is more than 35 percent. The high rate of death has led the medical community to try to understand the formation and natural history of these lesions to define standards for screening, treatment and identification of those CAs that are likely to rupture.

Other institutions include: Department of Neurosurgery and Institute of Forensic Medicine Heinrich-Heine University Institute for Physiological Chemistry and Pathobiochemistry, Westfalian Wilhelms-University; Department of Neurology, Mayo Clinic; Department of Epidemiology, University of Iowa; Division of Neurosurgery, St. Michael's Hospital;  Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute of St. Michael's Hospital; and the Department of Surgery,University of Toronto.

Anne Stark | Eurek Alert!
Further information:
https://www.llnl.gov/news/newsreleases/2014/May/NR-14-05-06.html#.U4iPLWGKDcs

Further reports about: Biomedical Department Epidemiology Neurosurgery atmosphere biosphere carbon-14 cerebral protein

More articles from Health and Medicine:

nachricht Multiple pathways progressing to Alzheimer's disease
26.06.2015 | University of California - San Diego

nachricht Researchers uncover epigenetic switches that turn stem cells into blood vessel cells
26.06.2015 | University of Illinois at Chicago

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Iron: A biological element?

Think of an object made of iron: An I-beam, a car frame, a nail. Now imagine that half of the iron in that object owes its existence to bacteria living two and a half billion years ago.

Think of an object made of iron: An I-beam, a car frame, a nail. Now imagine that half of the iron in that object owes its existence to bacteria living two and...

Im Focus: Thousands of Droplets for Diagnostics

Researchers develop new method enabling DNA molecules to be counted in just 30 minutes

A team of scientists including PhD student Friedrich Schuler from the Laboratory of MEMS Applications at the Department of Microsystems Engineering (IMTEK) of...

Im Focus: Bionic eye clinical trial results show long-term safety, efficacy vision-restoring implant

Patients using Argus II experienced significant improvement in visual function and quality of life

The three-year clinical trial results of the retinal implant popularly known as the "bionic eye," have proven the long-term efficacy, safety and reliability of...

Im Focus: Lasers for Fast Internet in Space – Space Technology from Aachen

On June 23, the second Sentinel mission was launched from the space mission launch center in Kourou. A critical component of Aachen is on board. Researchers at the Fraunhofer Institute for Laser Technology ILT and Tesat-Spacecom have jointly developed the know-how for space-qualified laser components. For the Sentinel mission the diode laser pump module of the Laser Communication Terminal LCT was planned and constructed in Aachen in cooperation with the manufacturer of the LCT, Tesat-Spacecom, and the Ferdinand Braun Institute.

After eight years of preparation, in the early morning of June 23 the time had come: in Kourou in French Guiana, the European Space Agency launched the...

Im Focus: Superslippery islands (but then they get stuck)

A simple reversible process that changes friction in the nanoworld

(Nano)islands that slide freely on a sea of copper, but when they become too large (and too dense) they end up getting stuck: that nicely sums up the system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Conference on Regenerative Medicine in Leipzig: Last chance to submit abstracts until 2 July

25.06.2015 | Event News

World Conference on Regenerative Medicine: Abstract Submission has been extended to 24 June

16.06.2015 | Event News

MUSE hosting Europe’s largest science communication conference

11.06.2015 | Event News

 
Latest News

Breaking through a double wall with a sledgehammer

29.06.2015 | Life Sciences

Lean but sated: Molecular Switch for a Healthy Metabolism discovered

29.06.2015 | Life Sciences

Spintronics Advance Brings Wafer-Scale Quantum Devices Closer to Reality

29.06.2015 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>