Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A tool to better screen and treat aneurysm patients

30.05.2014

New research by an international consortium, including a researcher from Lawrence Livermore National Laboratory, may help physicians better understand the chronological development of a brain aneurysm.


A cerebral aneurysm is a blood-filled bulge formed in response to a weakness in the wall at branching brain arteries. If the bulge bursts (shown left), the person can undergo a brain hemorrhage, which is a subtype of stroke and a life-threatening condition. An international team including a researcher from Lawrence Livermore found that the main structural constituent and protein in cerebral aneurysms is distinctly younger than once thought. The new research helps identify patients more likely to suffer from an aneurysm and embark on a path toward prevention.

Using radiocarbon dating to date samples of ruptured and unruptured cerebral aneurysm (CA) tissue, the team, led by neurosurgeon Nima Etminan, found that the main structural constituent and protein -- collagen type I -- in cerebral aneurysms is distinctly younger than once thought.

The new research helps identify patients more likely to suffer from an aneurysm and embark on a path toward prevention.

Simplified, a CA is a blood-filled bulge formed in response to a weakness in the wall at branching brain arteries. If the bulge bursts, the person can undergo a brain hemorrhage, which is a subtype of stroke and a life-threatening condition.

For decades, doctors have assumed that CAs rarely undergo structural change, and earlier theories speculated that CAs grow at a constant rate. The new findings, which appear in the June print issue of the journal Stroke, challenge the concept that CAs are present for decades and that they undergo only sporadic episodes of structural change. In view of these findings, it seems more likely that they alternate between periods of stability and instability during which they are prone to rupture.

For patients with CAs, who are more likely to undergo an aneurysm rupture due to risk factors such as smoking or hypertension, the international team including LLNL's Bruce Buchholz found that the age of collagen type I was significantly younger than those samples taken from people with no risk factors.

The ample amount of relatively young collagen type I in CAs suggests that collagen is changing all the time in aneurysms, which is significantly more rapid in patients with risk factors, Buchholz said.

Radiocarbon bomb-pulse dating uses an isotopic signature created by above-ground nuclear testing between 1955 and 1963, which nearly doubled the amount of carbon-14 in the atmosphere.

When the above-ground test-ban treaty took effect in 1963, atmospheric levels of radiocarbon began to decline as carbon-14 migrated into the oceans and biosphere. Living organisms naturally incorporate carbon into their tissues as the element moves through the food chain. As a result, the concentration of carbon-14 leaves a permanent time stamp on every biological molecule.

"This research may help doctors to formulate better screening and identification of those people at increased risk of an aneurysm rupture," Buchholz said.

The prevalence of unruptured CAs in the general population is 2 percent to 3 percent. The rate of death when they rupture is more than 35 percent. The high rate of death has led the medical community to try to understand the formation and natural history of these lesions to define standards for screening, treatment and identification of those CAs that are likely to rupture.

Other institutions include: Department of Neurosurgery and Institute of Forensic Medicine Heinrich-Heine University Institute for Physiological Chemistry and Pathobiochemistry, Westfalian Wilhelms-University; Department of Neurology, Mayo Clinic; Department of Epidemiology, University of Iowa; Division of Neurosurgery, St. Michael's Hospital;  Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute of St. Michael's Hospital; and the Department of Surgery,University of Toronto.

Anne Stark | Eurek Alert!
Further information:
https://www.llnl.gov/news/newsreleases/2014/May/NR-14-05-06.html#.U4iPLWGKDcs

Further reports about: Biomedical Department Epidemiology Neurosurgery atmosphere biosphere carbon-14 cerebral protein

More articles from Health and Medicine:

nachricht Tuning light to kill deep cancer tumors
16.10.2014 | University of Massachusetts Medical School

nachricht Study reveals optimal particle size for anticancer nanomedicines
16.10.2014 | University of Illinois College of Engineering

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

Battery Conference April 2015 in Aachen

16.10.2014 | Event News

Experts discuss new developments in the field of stem cell research and cell therapy

10.10.2014 | Event News

Zoonoses: Global collaboration is more important than ever

07.10.2014 | Event News

 
Latest News

Drive System Saves Space and Weight in Electric Cars

20.10.2014 | Automotive Engineering

A new digital world: Pictures of the Future online

20.10.2014 | Press release

Siemens gas and steam turbines powering Dow in Stade, Germany

17.10.2014 | Press release

VideoLinks
B2B-VideoLinks
More VideoLinks >>>