Lihong Wang, PhD, continues to build on his groundbreaking technology that allows light deep inside living tissue during imaging and therapy.
In the Jan. 5 issue of Nature Communications, Wang, the Gene K. Beare Professor of Biomedical Engineering at Washington University in St. Louis, reveals for the first time a new technique that focuses diffuse light inside a dynamic scattering medium containing living tissue. In addition, they have improved the speed of optical focusing deep inside tissue by two orders of magnitude. This improvement in speed is an important step toward noninvasive optical imaging in deep tissue and photodynamic therapy.
Washington University in St. Louis
Lihong Wang, PhD
In the new research, Wang and his team have built on a technique they developed in 2010 to improve the focusing speed of time-reversed ultrasonically encoded (TRUE) optical focusing for applications in living tissue. To focus light, the engineers use a virtual internal guide star at the targeted location. By detecting the wavefront of light emitted from the guide star, they can determine an optimum phase pattern that allows scattered light moving along different paths to focus at the targeted location.
When light is shined into living biological tissue, breathing and blood flow changes the optical interference, or speckle pattern, which can cause previous methods to focus diffuse light inside scattering media to fail. Scientists have to act quickly to get a clear image.
The new TRUE technology combines two techniques: focused ultrasonic modulation and optical phase conjugation. Researchers use a type of mirror to record then time-reverse the ultrasound-modulated light emitted from the ultrasonic focus to achieve the best focus. Previously, technology limited the speed of TRUE focusing to no more than 1 Hz.
To overcome this obstacle, the team used a fast-responding photorefractive crystal that is sensitive to light at the 790-nanometer wavelength, making it suitable to focus light deep into biological tissue. The new TRUE technology is able to focus light inside a dynamic medium with a speckle correlation time as short as 5.6 milliseconds. The improved speed allowed Wang to achieve the first optical focusing of diffuse light inside a scattering medium containing living biological tissue.
Going forward, the team plans to implement the system in a reflection configuration, where light is shined and detected on the same side of the tissue.
The School of Engineering & Applied Science at Washington University in St. Louis focuses intellectual efforts through a new convergence paradigm and builds on strengths, particularly as applied to medicine and health, energy and environment, entrepreneurship and security. With 91 tenured/tenure-track and 40 additional full-time faculty, 1,300 undergraduate students, more than 900 graduate students and more than 23,000 alumni, we are working to leverage our partnerships with academic and industry partners — across disciplines and across the world — to contribute to solving the greatest global challenges of the 21st century.
Liu Y, Lai P, Ma C, Xu X, Grabar A, Wang LV. Optical focusing deep inside dynamic scattering media with near-infrared time-reversed ultrasonically encoded (TRUE) light. Nature Communications, online Jan. 5, 2015. DOI: 10.1038/ncomms6904.
Funding from the National Institutes of Health (DP1 EB016986 and R01 CA186567) supported this research.
Asst. Vice Chancellor for Campus Communications
Julie Flory | newswise
Artificial intelligence may help diagnose tuberculosis in remote areas
25.04.2017 | Radiological Society of North America
Pharmacoscpy: Next-Generation Microscopy
25.04.2017 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
27.04.2017 | Life Sciences
27.04.2017 | Physics and Astronomy
27.04.2017 | Earth Sciences