Researchers have made two new scientific points with a set of experiments in which they induced people to perceive colors that weren't really there -- one concerning how the brain works and the other concerning how to work the brain.
Working with colleagues in Japan, the scientists at Brown University used a novel technique to surreptitiously train a small group of volunteers to associate vertical stripes with the color red and -- to a lesser extent as a consequence -- horizontal stripes with the color green.
The first point made by the researchers was that the association was induced by specifically targeting the early visual areas of the brain. Those "V1" and "V2" areas are the first parts of the cortex to process basic visual information coming from the eyes, but scientists had not previously seen associative learning occurring there.
"This is the first clear study that shows that V1 and V2 are capable of creating associative learning," said Takeo Watanabe, the Fred M. Seed Professor of Cognitive and Linguistic Sciences at Brown and co-corresponding author of the paper in the journal Current Biology.
The second point is that the association was learned strongly enough that subjects came to perceive the background colors paired with vertical bars as red even when the background was gray or sometimes a bit greenish. That learned misperception was evident in tests as much as five months later.
The demonstration raises the possibility that the training method could be used to induce other enduring associations in the brain, Watanabe said.
To assign association
Here is how Watanabe's team induced the association:
With volunteers in the magnetic resonance imaging scanner, the first step was to measure patterns of activity in V1 and V2 when they saw different combinations of colored backgrounds (red, green and gray) behind two different stripe orientations (vertical and horizontal). The researchers used that data to encode a "classifier" that could distinguish between red and green to recognize the brain activity the volunteers induced in those areas in future experiments.
Then the experimenters engaged in a subterfuge even greater than a little mind reading. With the intent of training 12 of their 18 volunteers to associate red with vertical stripes, they showed them gray backgrounded vertical stripes embedded within a circle and then a small plain white disk. They asked the volunteers to imagine ways of making the disk larger. The volunteers were offered a reward based on the size of the disk they could produce.
Over three days of such training, volunteers thought of a variety of ways they might use their brains to enlarge the disk, but really the disk only got larger when the classifier saw signs they were thinking of red (for whatever coincidental reason). In other words, the 12 volunteers were really being trained such that after seeing vertical stripes they would induce activity patterns in V1 and V2 similar to the activity that had occurred when they actually saw red.
"Participants were not aware of the purpose of the experiment or what kind of activation they learned to induce," Watanabe said.
After the 12 volunteers had been trained and the six others were left untrained, the researchers then measured their visual perceptions. Both groups of volunteers were shown circles with central patterns of vertical, horizontal or diagonal stripes. Each of those patterns had backgrounds colored somewhere along a continuum of eight settings ranging from obviously to faintly green to gray to faintly to obviously red.
The key question was whether the trained and untrained subjects would exhibit any differences in the colors they perceived in the backgrounds behind the vertical stripes. Sure enough, trained subjects were significantly more likely than untrained ones to perceive the gray background of vertical stripes -- and even the faintly green background -- as red. Meanwhile, trained subjects were more likely to associate backgrounds behind horizontal stripes as greener than untrained subjects.
Neither group showed any incorrect color bias in judging the backgrounds behind the diagonal stripes. In testing up to five months later, however, trained subjects still showed significant associations for vertical gratings.
Applications of associations
Associative learning and memory -- "this goes with that" -- is pervasive in the brain, but it was a novel finding of basic brain science to show that it can occur in early visual areas, Watanabe said.
In a more applied vein, Watanabe said he is eager to find out if scientists can use the study's technique of training subjects with (unwitting) MRI-based feedback to create associations in other parts of the brain for educational or therapeutic reasons.
"Our brain functions are mostly based on associative processing, so association is extremely important," Watanabe said. "Now we know that this technology can be applied to induce associative learning."
Through the technique, which Watanabe calls A-DecNef, perhaps people can learn even when they don't know what they are learning, or that they are learning at all.
The paper's lead author is Kaoru Amano of Center for Information and Neural Networks (CiNet) in National Institute of Information and Communications Technology. The co-corresponding author is Mitsuo Kawato of the Advanced Telecommunications Research Institute International in Japan. The other authors are Kazuhisa Shibata and Yuka Sasaki of Brown.
The National Institutes of Health, the National Science Foundation and the government of Japan supported the research.
David Orenstein | EurekAlert!
Noninvasive eye scan could detect key signs of Alzheimer's years before patients show symptoms
18.08.2017 | Cedars-Sinai Medical Center
Water-filtered infrared-A (wIRA) overcomes swallowing disorders and hypersalivation – a case report
10.08.2017 | Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V.
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
18.08.2017 | Life Sciences
18.08.2017 | Physics and Astronomy
18.08.2017 | Materials Sciences