A screening method that combines a traditional PSA test with an MRI detects a significantly greater number of prostate cancer cases and improves diagnostic accuracy. The study was conducted as part of the largest international research project on prostate cancer. The method will now be tried with 40,000 subjects in Gothenburg.
Prostate cancer, which is the third most common malignancy among European men, caused more than 92,000 deaths in 2012 alone.
Anna Grenabo-Bergdahl, Researcher, University of Gothenburg
University of Gothenburg
Sweden and many other countries use the PSA test for diagnostic purposes. The test has been widely criticized for yielding false negatives, as well as false positives that lead to needless assessment and treatment.
As a result, Swedish authorities have not issued a general recommendation for PSA screening.
As part of a large European research project, scientists at Sahlgrenska Academy, University of Gothenburg, have studied a method that combines the PSA test with an MRI. Based on 384 Swedish subjects and presented in a doctoral thesis, the study concludes that the method can improve detection of more aggressive forms of prostate cancer.
"Additional research is required to confirm our findings, but the pilot study indicates that combining a PSA test with an MRI reduces the need for follow-up biopsies," says Anna Grenabo-Bergdahl, co-director of the study along with Professor Jonas Hugosson. "Depending on the PSA cut-off used, we can improve detection of potentially aggressive cancer while bypassing low-risk tumors that are generally of no clinical significance."
More precise biopsy
An MRI also facilitates identification of a possible malignant area such that any follow-up biopsy will be much more precise.
"That way the patient experiences less stress and clinicians are not as prone to overlook high-risk tumors," Dr. Grenabo-Bergdahl says.
The Swedish pilot study won the award for the best abstract by a resident at the Madrid conference of the European Association of Urology in late March.
Study on 40,000 subjects
The upcoming study will involve 40,000 subjects in the Gothenburg area.
"A repetition of the findings of the pilot study may be the opening shot of a paradigm shift in screening and early detection of prostate cancer," Dr. Grenabo-Bergdahl says.
Burden of unnecessary costs
The evidence is not in yet as to whether MRI is a cost-effective option for routine screening.
"Such an estimate must consider the costs associated with overdiagnosis under the current system," Dr. Grenabo-Bergdahl says. "Many men who are diagnosed with prostate cancer on the basis of a PSA test are old enough that low-risk tumors will never pose any kind of danger to their health. Not only does the healthcare system bear the burden of unnecessary costs, but the patient's quality of life is compromised by worry and risky treatment. If the use of MRIs can help minimize such incidents while detecting more potentially aggressive tumors, it will represent genuine progress on all scores".
Dr. Grenabo-Bergdahl defended Characteristics of screen-failures in prostate cancer screening on April 17.
Link to the thesis: https://gupea.ub.gu.se/handle/2077/38003
Anna Grenabo-Bergdahl, Researcher, Sahlgrenska Academy, University of Gothenburg
Henrik Axlid | idw - Informationsdienst Wissenschaft
Wireless power can drive tiny electronic devices in the GI tract
28.04.2017 | Brigham and Women's Hospital
Artificial intelligence may help diagnose tuberculosis in remote areas
25.04.2017 | Radiological Society of North America
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences