For epilepsy patients and attending physicians, it has been a challenge to correctly assess the frequency and severity of epileptic seizures without inpatient recording equipment. A consortium coordinated by the epileptologists of the University Hospital Bonn is now developing a mobile sensor that can detect seizures. A warning signal is designed to summon relatives or attending physicians to provide timely help. The project "EPItect" will receive about two million Euro in subsidies from the German Federal Ministry of Research (BMBF) over the next three years. 635,000 Euro will go to Bonn. The consortium will receive support from the project sponsor VDI/VDE Innovation + Technik GmbH.
Epileptic seizures can take very different courses: Some of those affected smack their lips; others engage in unmotivated fumbling with their clothing; others "go out" completely for a short time; and some actually suffer the muscular twitching that is considered typical.
Telemedicine for epilepsy patients: Prof. Dr. Christian Elger (right) and Private Docent Dr. Rainer Surges of the Department of Epileptology of the University Hospital Bonn with the minisensor.
© Photo: Barbara Frommann/Uni Bonn
"It is not easy to classify all the symptoms correctly", says Prof. Dr. Christian E. Elger, Director of the Department of Epileptology of the University Hospital Bonn. Some of the seizures even occur during sleep; those affected often don't notice anything at all. "We estimate that the patients consciously perceive a maximum of half their seizures", adds Private Docent Dr. Rainer Surges, lead consultant at the Department of Epileptology at the University Hospital Bonn and coordinator of the joint project.
This subjective misperception of the frequency and strength of seizures impedes both the diagnosis and treatment of epilepsy. The "thunderstorms in the brain" can usually be recorded clearly using electroencephalography, but that requires a hospital stay.
"Mobile measuring devices could be integrated much better into the everyday activities of patients", says Dr. Surges. Just such a mobile miniature sensor system is currently under development by a consortium led by the Department of Epileptology of the University Hospital Bonn. The project "EPItect" will receive about two million Euro in subsidies from the German Federal Ministry of Research (BMBF) over the next three years, including 635,000 Euro for the Bonn Hospital.
Minisensor measures symptoms in the ear
The company Cosinuss GmbH in Munich has already developed an epilepsy sensor, which is placed in the ear like a hearing aid. The measuring device will be miniaturized even further and optimized for this purpose. "In a preliminary study sponsored by the Marga and Walter Boll Foundation, we found that epileptic seizures can be detected very well via an accelerated pulse and certain patterns of movement", reports Dr. Surges. These symptoms can be measured by the little ear bud.
It is designed to transmit the signals via a connected smartphone to a central computer that continuously checks the incoming data for abnormalities and to warn patients, relatives, and attending physicians if necessary. This is because, in the worst case, epileptic seizures can end in death, for instance due to serious accidents with fatal injuries or due to cardiac arrest in the so-called sudden unexpected death in epilepsy.
More autonomy and easier care for patients
The focus of the project is to develop such automated data and alarm chains and to test and optimize them together with epilepsy patients, relatives, and caregivers. EPItect is designed to make the lives of patients easier and provide assistance in many ways: "Epilepsy patients are often afraid of unpredictable seizures in public", reports Dr. Surges. They can be expected to regain more autonomy, if they can better estimate the current risk of a seizure.
Relatives do not have to be afraid that patients will not get care if a new seizure occurs, because a doctor could be called automatically. And the signals of the in-ear sensor give scientists much more reliable data. "With EPItect we can expect to make better diagnoses, because the frequency and severity of seizures can be recorded better", says Prof. Elger. The same goes for the development of new therapies: In clinical studies, the mobile mini-sensor can be used to provide more reliable data, for example regarding the drug that reduces the seizures most effectively.
The EPItect project includes not only adults but also younger patients. "Since many children and adolescents also suffer from epilepsy, we hope to achieve important progress for this target group using the sensor system", says Prof. Dr. Ulrich Stephani, Director of the Department of Neuropediatrics at the Schleswig-Holstein University Hospital in Kiel. The consortium plans to have the new technology available for patients and clinical trials in a few years. In the first step, a study will be done with selected patients. Later EPItect will be made available to a broader group of patients. "In epileptology we are just at the beginning of a breakthrough in mobile healthcare technologies and telemedicine", says Dr. Surges.
The partners in the EPItect consortium
The EPItect consortium consists of five institutions and two associated partners in Germany: Department of Epileptology at the University Hospital Bonn, Fraunhofer Institute for Software and Systems Technology ISST, Department of Neuropediatrics of the University of Kiel (UKSH), the North German Epilepsy Center in Schwentinental-Raisdorf, Cosinuss GmbH Munich, the University for Healthcare Professions in Bochum, and the Epilepsy Bundes-Elternverband e.V. [National Epilepsy Parents Network] in Wuppertal.
Contact for the media:
Private Docent Dr. med. Rainer Surges
Department of Epileptology
University of Bonn Medical Center
Johannes Seiler | idw - Informationsdienst Wissenschaft
Novel PET tracer identifies most bacterial infections
06.10.2017 | Society of Nuclear Medicine and Molecular Imaging
Teleoperating robots with virtual reality
05.10.2017 | Massachusetts Institute of Technology, CSAIL
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
19.10.2017 | Materials Sciences
19.10.2017 | Materials Sciences
19.10.2017 | Physics and Astronomy