The Fraunhofer-Gesellschaft, on behalf of the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, has signed an asset transfer agreement with Takeda GmbH to exclusively transfer its Surfactant and Continuous Powder Aerosolization (CPA) program assets to Fraunhofer ITEM.
The transfer includes the CPA technology for continuous aerosolization of powdery substances and the know-how to manufacture recombinant surfactant protein C, together with the associated intellectual property. The Fraunhofer ITEM is thus in a position to continue the development of therapies involving continuous inhalation various medications, begun 10 years ago.
Closing down its respiratory department, Takeda transferred its Surfactant and CPA program assets to Fraunhofer ITEM including the associated intellectual property. The CPA technology is the first non-invasive administration method for powdery surfactant drugs.
Surfactant drugs have to be administered to patients with surfactant deficiency, which is common, for example, in preterm in neonates. Furthermore, this therapeutic approach has been investigated in other acute and chronic life-threatening diseases such as acute lung injury and COPD.
Surfactant (“surface-active agent“) is secreted by certain lung cells und reduces surface tension in the alveoli, thereby preventing their collapse. Physical activity causes an increase, smoking a decrease in surfactant production. Fetal surfactant production starts in week 24 of gestation. Preterm neonates, in particular if born before week 34 of gestation, suffer from varying degrees of pulmonary surfactant deficiency, which may lead to neonate respiratory distress syndrome.
Surfactant-based therapy is the standard of care. Its use is limited, however, due to the currently invasive administration methodology. The CPA technology simplifies surfactant delivery to neonates and can also be used for children and adults. Recombinant surfactant protein C is the first recombinant surfactant protein suitable for use in synthetic surfactant drugs.
CPA is also a suitable technology to continuously deliver pulmonary high doses of non-soluble drugs to patients. In respiratory care, the standard of aerosolization for continuous inhalation is currently confined to different classes of nebulizers. In contrast, the CPA technology for the first time enables continuous inhaled administration of non-soluble drugs. In addition, it delivers a higher drug concentration to patients and enables a higher lung deposition rate.
Dr. Gerhard Pohlmann, Head of Medical Inhalation Technology at Fraunhofer ITEM with a 10+ year track record in CPA technology development, said: “As a long-standing partner in the CPA program, Fraunhofer ITEM is delighted to continue development of the surfactant and CPA technology platform. We are currently in the strategic process of reorganizing the program and selecting development partners.”
Dr. Gerhard Pohlmann; +49 511 5350-116
Dr. Cathrin Nastevska; +49 511 5350-225
The text of this press release can be found on our homepage at
Dr. Cathrin Nastevska | Fraunhofer Institute for Toxicology and Experimental Medicine
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