Researchers at the University of Minnesota Stem Cell Institute are one step closer to understanding how blood cells develop through the use of human embryonic stem cells. The research better defines the conditions under which blood cell development occurs, making the process easier to replicate. The findings are published in the October issue of Experimental Hematology.
"These findings do more than give us a basic understanding of blood cell replacement--they allow us to consider potential future therapies," said Dan Kaufman, M.D., assistant professor of medicine in the division of hematology, oncology and lead researcher. "We can envision blood therapies completely compatible with the patient, such as use of embryonic stem cells to make red blood cells for platelets used in blood transfusions, or a source of new blood supply free of any viruses. They might also be a source for bone marrow transplants, especially for those patients who do not otherwise have an appropriately matched donor."
This process is also significant because the blood cells were developed without the use of animal serum, which was previously thought to be essential for blood cell development. Instead, specific growth factors are added to guide the cell differentiation. These results are important for potential human application. Animal serum can potentially contaminate findings and create complications for human trials.
Kaufmans research interests focus on hematopoietic and endothelial cell development from human and non-human primate embryonic stem cells. This research uses embryonic stem cells to understand the earliest stages of blood cell development.
Molly Portz | Source: EurekAlert!
Further information: www.umn.edu
More articles from Life Sciences:
Genome sequence for the domestic horse to be unveiled
06.11.2009 | University of California - Davis
Common plants can eliminate indoor air pollutants
06.11.2009 | American Society for Horticultural Science
Airborne nitrogen shifts aquatic nutrient limitation in pristine lakes
06.11.2009 | Studies and Analyses
Genome sequence for the domestic horse to be unveiled
06.11.2009 | Life Sciences
06.11.2009 | Earth Sciences
Texas Tech University Hosts Major Textile Conference in India
06.11.2009 | Event News
Brief Highlights of the Fluid Dynamics Conference, Minneapolis
30.10.2009 | Event News
EUROSAFE Forum 2009 Brussels: "Safety Implications of an Increased Demand for Nuclear Energy"
29.10.2009 | Event News