Using cell cultures, German researchers show how the drug may regulate the energy balance in damaged body cells
A diabetes drug might help in certain types of Parkinson’s disease, reports a team of German brain researchers headed by Dr. Julia Fitzgerald at the Hertie Institute for Clinical Brain Research, the University of Tübingen and the German Center for Neurodegenerative Diseases in Tübingen.
The neuroscientists identified a protein that plays an important role in the energy balance of cells. If the protein is missing, the energy balance is disturbed leading possibly to cell death and ultimately to the onset of the disease.
In Parkinson’s disease, nerve cells die off in a brain area responsible for movement control. Using cell cultures, the research team has now shown that the diabetes drug metformin acts on the energy budget, thereby protecting the cells. The study has been published in the current issue of the journal Brain.
“When studying cells from a patient suffering from Parkinson’s disease we saw that they lack an important protein which regulates the energy production,” explains Fitzgerald. As a result, the cells keep on producing energy in their mitochondria—the cells’ powerhouses—unchecked and less regulated.
Energy production comes at the cost of the generation of free oxygen radicals. The radicals damage the cell and lead to aging and, in the long term, sometimes to cell death. “The diabetes drug acts like a brake in this process. It slows down the uncontrolled generation of energy, thereby protecting the cells from the negative effects,” the researcher reports.
The study by the Tübingen neuroscientists provides another indication that diabetes drugs might have a positive influence on certain types of Parkinson’s disease. “Only recently, an Anglo-American research collaboration showed that another diabetes drug can reduce movement disorder symptoms in patients with Parkinson’s disease,” says Fitzgerald.
The new findings of Fitzgerald and her colleagues contribute to the development of personalized medicine which aims at treating the disease with interventions tailored to the underlying individual trigger factor in each patient. In Parkinson’s disease, both hereditary predisposition and environmental influences play a role in the development of the disease.
“Ultimately, the cause varies from person to person,” explains Fitzgerald. “In the long term, our study will be beneficial to patients suffering from faulty energy production in cells.” At present, there are no drugs available that may stop or slow down Parkinson’s disease, physicians may only treat symptoms. Worldwide, there are about 10 million people affected by the
Fitzgerald et al. (2017): Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson’s disease. Brain 140(9), pp 2444–2459.
Dr. Julia Fitzgerald
Hertie Institute for Clinical Brain Research
University of Tübingen
Phone: +49 7071 29-87616
Dr. Mareike Kardinal | idw - Informationsdienst Wissenschaft
New application for acoustics helps estimate marine life populations
16.01.2018 | University of California - San Diego
Unexpected environmental source of methane discovered
16.01.2018 | University of Washington Health Sciences/UW Medicine
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
17.01.2018 | Ecology, The Environment and Conservation
17.01.2018 | Physics and Astronomy
17.01.2018 | Awards Funding