Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Using “big data” to fight flu


Thanks to “big data”, researchers have identified new molecules that are instrumental in the replication of the flu virus. If these host proteins are blocked, influenza viruses are unable to multiply as effectively. The international study therefore makes a significant contribution towards the development of new treatments and flu drugs.

Flu epidemics occur almost every year. Sometimes, novel virus strains can even spread into global pandemics. In recent years, influenza A viruses (IAV) have been discovered that are resistant to the drugs available to treat flu, which can result in patients not responding to the medication.

The replication of influenza A viruses (IAV) can be stopped thanks to "big data".

(Image: fotoliaxrender)

The flu is triggered by infections with influenza viruses, which multiply heavily in the respiratory tract. In order to replicate within the cells of the respiratory tract, the viruses rely on host molecules. In recent years, there have thus been attempts to identify and block key host molecules for this process in order to stop the virus in its tracks.

Inhibition of host proteins curbs viral growth

An international study, in which the University of Zurich is involved, also pursues this approach. The research teams from Switzerland, Germany and the USA analyzed datasets from independent publications on IAV host molecules. These studies focus on the totality of the genes (“GenOMICs”) and proteins (ProteOMICs”) required for the virus and generate a vast quantity of data. Thanks to the comprehensive analysis of these “OMIC” databases, 20 previously unknown host molecules that promote the growth of influenza A viruses have been discovered.

“These unchangeable host proteins are vital for the replication of the viruses,” explains Professor Silke Stertz from the Institute of Medical Virology at the University of Zurich. “We can now use these to stop the virus from spreading further.” One of these host proteins is UBR4, which the virus needs to transport viral proteins to the cell membrane and construct new particles. This takes place as follows: The influenza A virus invades the host cell. The viral components are then carried to the cell surface, where they form new viruses. Consequently, as many as 20,000 new influenza viruses can develop from one, single infected host cell.

The study reveals that blocking UBR4 inhibits the production of new virus particles in infected cells. In mice, for instance, the IAV replication could be weakened and the progress of the disease slowed. The study therefore provides evidence that blocking host molecules is feasible as a therapeutic strategy for the treatment of influenza.

Public web portal supports drug development

The research team created a simplified, user-friendly web portal ( on influenza and host interaction. The site is also accessible to other researchers, enables individual requests and provides analysis tools to trace host proteins that are probably involved in the flu infection. As a result, the data published may help develop the next generation of influenza medication.

“We expect the approach described in this study and the use of ‘big data’ to bridge the gap between biomedical research and therapeutic development, and facilitate fresh insights into previously unanswered medical questions,” says co-author Sumit Chanda from Sanford Burnham Prebys Medical Discovery Institute (SBP) in California.

Shashank Tripathi, Marie O. Pohl, ….,Silke Stertz et al.: Meta- and Orthogonal Integration of Influenza 'OMICs' Data Reveals UBR4 as a Critical Regulator of M2 Ion Channel Membrane Trafficking. Cell Host & Microbe, December 9, 2015.

Marie-Theres Pohl
Institute of Medical Virology
University of Zurich

Weitere Informationen:

Melanie Nyfeler | Universität Zürich

More articles from Life Sciences:

nachricht Biologists unravel another mystery of what makes DNA go 'loopy'
16.03.2018 | Emory Health Sciences

nachricht Scientists map the portal to the cell's nucleus
16.03.2018 | Rockefeller University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>