Even though the transplantation of blood stem cells, also known as bone marrow, has saved many lives over many decades, the genes that control the number or function of blood stem cells are not fully understood. In a study published in June in Stem Cell Reports, the USC Stem Cell labs of Hooman Allayee and Gregor Adams uncovered new genes that affect blood stem cell development and maintenance.
The Allayee and Adams labs performed a genetic screen of a collection of more than 100 mouse strains that are commonly used in laboratories, called the hybrid mouse diversity panel.
The researchers found that different strains have different numbers of several important sub-populations of blood stem cells, including those called "short-term HSCs," which are responsible for the formation of red and white blood cells in adults. The activation of a gene called Hopx is associated with an increased number of short-term HSCs. The researchers further proved this finding by showing that mice lacking the Hopx gene form fewer short-term HSCs and are ineffective bone marrow donors.
"Short-term HSCs are the major stem cells in the adult bone marrow, so finding new genetic regulators of this subpopulation may have clinical benefits," said Adams.
More broadly, the researchers have shown that the hybrid mouse diversity panel can be used to find genes that would otherwise go unnoticed.
"This powerful genetics platform has the potential to reveal the genes underlying other stem cell populations or a wide range of diseases that would be difficult to study in humans," said Allayee.
The paper's lead authors are Xiaoying Zhou and Amanda L. Crow from USC, and additional contributors include: Jaana Hartiala, Tassja J. Spindler and Lora W. Barksy from USC; Anatole Ghazalpour, Brian W. Parks, Eleazar Eskin and Aldons J. Lusis from UCLA; Brian B. Bennett from the University of North Carolina, Chapel Hill; and Rajan Jain and Jonathan A. Epstein from the University of Pennsylvania.
This work was supported by the California Institute for Regenerative Medicine (grant TG2-01161), the National Institutes for Health (grants T32ES013678, K99HL102223, K99HL123021, R01ES022282, R01HL071546, P01HL30568, P01HL28481, R01ES021801, 3R01ES021801-03S1, UL1TR000130 and P3ES007048) and the Margaret E. Early Medical Research Trust.
Cristy Lytal | EurekAlert!
Signaling Pathways to the Nucleus
19.03.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
In monogamous species, a compatible partner is more important than an ornamented one
19.03.2018 | Max-Planck-Institut für Ornithologie
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
19.03.2018 | Physics and Astronomy
19.03.2018 | Materials Sciences
19.03.2018 | Event News