Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Understanding signaling pathways, fighting the spread of cancer


Collaborative Research Center at the University of Freiburg enters its third and final funding period

The German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) has approved the renewal application for the Collaborative Research Center (CRC, Sonderforschungsbereich, SFB) 850 “Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis”. The CRC 850 has been running since January 1, 2010 and will enter its third and final funding period starting at the beginning of 2018.

Christoph Peters is the spokesperson for the special research area "Control of Cell Mobility in Morphogenesis, Cancer Invasion and Metastasis." Photo: Britt Schilling/University Medical Center Freiburg

The DFG has assured a total of 12.7 million euros for the coming four years. Researchers from the Faculties of Biology and Medicine at the University of Freiburg along with the German Cancer Consortium, partner site Freiburg and the Max Planck Institute of Immunobiology and Epigenetics are collaborating in this CRC, which hitherto has brought forth more than 180 scientific publications.

Prof. Dr. Christoph Peters, Director of the Institute of Molecular Medicine and Cell Research and Scientific Director of Comprehensive Cancer Center Freiburg (CCCF) is the spokesperson.

Cell motility describes the cells’ ability to move actively. Uncontrolled cell motility is one of the key characteristics of malignant tumors. It allows the tumor cells to invade neighboring tissue, spread through the body and form colonies or so-called metastases in foreign organs. These metastases pose a huge problem in cancer medicine and are responsible for the majority of cancer related deaths.

Cell motility is controlled by central signaling pathways that are active during embryonic development and may be reactivated in malignant cancer cells. They play an essential role in the formation and spread of tumors.

The aim of the SFB 850 is to better understand the molecular mechanisms of these signaling pathways and to apply this knowledge to control the motility of cells, for example, through already existing drugs. These insights may also serve as basis for the development of new therapeutic strategies for inhibiting the invasion of cancer cells into healthy tissue and thereby to prevent the formation and growth of metastases.

The scientific background of the participating groups is wide ranging - from basic research in developmental biology to clinical cancer research in the CCCF, enabling a direct review of the clinical relevance of the obtained findings.

Further information

Prof. Dr. Christoph Peters
Institute of Molecular Medicine and Cell Research
University of Freiburg
Tel.: 0761/203-9601

Christoph Peters is the spokesperson for the special research area "Control of Cell Mobility in Morphogenesis, Cancer Invasion and Metastasis." Photo: Britt Schilling/University Medical Center Freiburg

Weitere Informationen:

Rudolf-Werner Dreier | Albert-Ludwigs-Universität Freiburg im Breisgau

More articles from Life Sciences:

nachricht Don't Give the Slightest Chance to Toxic Elements in Medicinal Products
23.03.2018 | Physikalisch-Technische Bundesanstalt (PTB)

nachricht North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Space observation with radar to secure Germany's space infrastructure

Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.

The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...

Im Focus: Researchers Discover New Anti-Cancer Protein

An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.

The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

New solar solutions for sustainable buildings and cities

23.03.2018 | Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

Latest News

For graphite pellets, just add elbow grease

23.03.2018 | Materials Sciences

Unique communication strategy discovered in stem cell pathway controlling plant growth

23.03.2018 | Agricultural and Forestry Science

Sharpening the X-ray view of the nanocosm

23.03.2018 | Physics and Astronomy

Science & Research
Overview of more VideoLinks >>>