A vaccination against type 1 diabetes will soon also be available to young children: the Pre-POINTearly vaccination study will involve children between the ages of six months and two years from across Germany who have a first-degree relative with type 1 diabetes. In the preceding Pre-POINT study a positive immune response was triggered in children aged between two and seven years with the aid of powdered insulin. The follow-up Pre-POINTearly study will now test whether this effect can be confirmed by giving very young children oral insulin, and whether type 1 diabetes can be prevented in the long term.
The insulin vaccination trial is a prime example of the excellent cooperation between universities and research institutes. Participants in the study are the Institute of Diabetes Research at the Helmholtz Zentrum München, the Paul Langerhans Institute Dresden at the Technische Universität Dresden, the German Center for Diabetes Research (DZD), the Technical University of Munich (TUM) and the Ludwig Maximilians University of Munich (LMU).
Source: Helmholtz Zentrum München
The new Pre-POINTearly vaccination study will treat children between the ages of six months and two years who carry a genetic risk of developing type 1 diabetes or have a family history of the disease, but who have not yet developed an autoimmune response.
As in the preceding Pre-POINT study, the participants will take the insulin in powder form with their food every day for twelve months. The daily dose will be gradually increased from 7.5 mg to 67.5 mg. Medical examinations will be conducted at three-month intervals in order to monitor the general health of the participants. In the preceding study, oral insulin was shown to be well tolerated and safe. Hypoglycemia or other adverse effects such as allergies did not occur.
Why oral insulin as a vaccine?
When insulin is given orally, it is absorbed through the mucous membranes of the mouth and the intestines, and is split into smaller components during the digestive process. That is why oral insulin – in contrast to insulin that is injected – has no influence whatsoever on blood sugar levels. Instead it acts like a vaccine that trains the immune system.
“The autoimmune response that causes type 1 diabetes in childhood is often initially directed at the insulin,” explains Prof. Anette-Gabriele Ziegler, Director of the Institute of Diabetes Research. The aim of the Pre-POINTearly study is therefore to build up immune tolerance to insulin and thus block the autoimmune process.” It is hoped that insulin in powder form will stimulate the growth of protective immune cells and thus prevent the destruction of beta cells.
The working group headed by Professor Joerg Hasford of the Institute for Medical Information Processing, Biometrics and Epidemiology at LMU Munich is responsible for the methodology, data coordination and statistical evaluation of the Pre-POINT and Pre-POINTearly studies.
For more information without obligation, please contact the Institute of Diabetes Research
Phone: 0800 - 828 48 68 (toll free in Germany)
Type 1 diabetes is becoming increasingly prevalent in children. Each year about six percent more children under the age of five are diagnosed than in the previous year. Often the autoimmune process, which precedes clinical symptoms of the disease, begins in the first two years of life. Early preventive steps must therefore be taken at this stage in a child’s development.
The Helmholtz Zentrum München, the German Research Center for Environmental Health, pursues the goal of developing personalized medical approaches for the prevention and therapy of common major diseases such as diabetes mellitus and lung disease. To that end, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum München has about 1,900 staff members and is headquartered in Neuherberg in northern Munich. It is a member of the Helmholtz Association, a community of 18 scientific-technical and medical-biological research centers with a total of about 31,000 staff members. www.helmholtz-muenchen.de
The Institute of Diabetes Research (IDF) focuses on the origins and prevention of type 1 and type 2 diabetes as a long-term effect of gestational diabetes. The development of an insulin vaccine to prevent type 1 diabetes is a high-priority project at the institute. In large-scale, long-term studies, the IDF examines the relationship between genetics, environmental factors and the immune system in the pathogenesis of type 1 diabetes. Using the data obtained from the birth cohort study BABYDIAB, which was established in 1989 as the first prospective diabetes birth cohort worldwide, both high-risk genes and antibody profiles can be identified. Based on this data, predictions can be made about the onset and development of type 1 diabetes which will alter both the classification and time of diagnosis of the disease. The IDF is part of the Helmholtz Diabetes Center (HDC).
The Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the University Clinic Carl Gustav Carus of TU Dresden (PLID) was founded in 2009 in the course of the establishment of the German Center for Diabetes Research e.V. In January 2015, the PLID also became a satellite institute of the German Research Center for Environmental Health in Munich. Since its establishment in 2009, eight professors and five independent group leaders could be recruited to join the PLID. This was possible due to intense collaborations between the PLID, the Center for Regenerative Therapies Dresden (CRTD), the Faculty of Medicine and the University Clinic Carl Gustav Carus and is also justified by the outstanding reputation of the Dresden Diabetes Research. The scientific focus of the PLID is on the molecular cell biology, the development, regeneration and protection of the beta cells of the islets of Langerhans in the pancreas for the therapy and the prevention of Type-1 and Type-2-Diabetes.
The German Center for Diabetes Research (DZD) is a national association that brings together experts in the field of diabetes research and combines basic research, translational research, epidemiology and clinical applications. The aim is to develop novel strategies for personalized prevention and treatment of diabetes. Members are Helmholtz Zentrum München – German Research Center for Environmental Health, the German Diabetes Center in Düsseldorf, the German Institute of Human Nutrition in Potsdam-Rehbrücke, the Paul Langerhans Institute Dresden of the Helmholtz Zentrum München at the University Medical Center Carl Gustav Carus of the TU Dresden and the Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München at the Eberhard-Karls-University of Tuebingen together with associated partners at the Universities in Heidelberg, Cologne, Leipzig, Lübeck and Munich.
In collaboration with the Institute of Diabetes Research at the Helmholtz Zentrum München, the Diabetes Research Group at the Technische Universität München (TUM) focuses on the causes of diabetes in children and young adults, early detection methods and prevention of the disease. It is also concerned with the development of the disease during pregnancy (gestational diabetes) as well as with risk factors for unborn babies and young infants associated with type 2 diabetes and obesity, and develops animal models for the study of diabetes.
The Institute for Medical Informatics, Biometry and Epidemiology (IBE) at the Ludwig-Maximilians-University of Munich covers the whole speciality from bioinformatics, epidemiology and public health research to biostatistics and clinical trials methodology in research, training and teaching. For over 20 years Prof. Dr. Joerg Hasford and his group mainly work on planning and statistical analysis of clinical trials as well as the forecasting research. The focus is on hemato-oncology and diabetes mellitus.
Contact for the media:
Department of Communication, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764 Neuherberg - Phone: +49 89 3187 2238 - Fax: +49 89 3187 3324 – E-mail: firstname.lastname@example.org
Scientific contact at Helmholtz Zentrum München:
Prof. Dr. Anette-Gabriele Ziegler, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Institute of Diabetes Research, Ingolstädter Landstr. 1, 85764 Neuherberg - Phone +49 89 3187 3405 - E-mail: email@example.com
Kommunikation | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel
Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
25.05.2018 | Event News
02.05.2018 | Event News
13.04.2018 | Event News
25.05.2018 | Event News
25.05.2018 | Machine Engineering
25.05.2018 | Life Sciences