Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The Effect of Statins Influenced by Gene Profiles

29.10.2014

The Montreal Heart Institute Research Centre is once again pushing the limits of knowledge in personalized medicine.

A meta-analysis combining the results of several pharmacogenomic studies and involving over 40,000 research subjects now makes it possible to demonstrate a different response to statins according to the patient's gene profile.

This important contribution of two Montreal researchers from the Montreal Heart Institute (MHI), Dr. Jean-Claude Tardif, Director of the Research Centre and Dr. Marie-Pierre Dubé, Director of the Pharmacogenomics Centre, was the subject of a scientific publication released today in the prestigious journal Nature communications.

"Once again, the Montreal Heart Institute and its team of committed doctors, researchers and professionals stand out as world leaders in the fight against cardiovascular diseases. This research project benefitted from our participation in this international consortium, leveraged by our knowledge and our pharmacogenomic laboratory dedicated to the search for innovative treatments in the fight against heart disease. 

Today, these advances make it possible to identify a different response to a statin commonly used to reduce LDL-cholesterol (bad cholesterol), according to the individual's gene profile. And for the first time, two genomic regions (loci) have been identified as determining responses to a statin," said Dr. Tardif as he highlighted the MHI Foundation's financial contribution towards the completion of this study.

Patients will benefit considerably in the medium and long term from these findings and innovations as the medical practices used to treat heart disease are transformed to allow each patient to receive suitable treatment. This is another of the MHI researchers' tangible contributions to the transformation of medical practices in the treatment of cardiovascular diseases.

Keep in mind that more than 1.3 million Canadians suffer from cardiovascular diseases, which are the world's primary cause of hospitalization and death. These diseases also put the greatest burden on our health system, with health costs nearing $22 billion per year.

About the Montreal Heart Institute

Founded in 1954 by Dr. Paul David, the Montreal Heart Institute fosters the highest standards of excellence in cardiology through its leadership in clinical and fundamental research, ultra-specialized care, professional training, and prevention. It is part of the vast network of excellence in health established by Université de Montréal and its affiliates. 

About the Montreal Heart Institute Foundation

The Montreal Heart Institute Foundation raises and administers funds to support the Montreal Heart Institute and its innovative and priority projects, and to assist the Institute in its fight against heart disease, the leading cause of death worldwide. Since its inception in 1977, the Foundation has granted more than $175 million to the Montreal Heart Institute.

 – 30 –

The study is available upon request.

Information:              

Julie Chevrette                                    

Public Relations Officer

Montreal Heart Institute Foundation                          

514 376-3330, extension 2641        

 julie.chevrette@icm-mhi.org

Julie Chevrette | Eurek Alert!

More articles from Life Sciences:

nachricht Tag it EASI – a new method for accurate protein analysis
20.06.2018 | Max-Planck-Institut für Biochemie

nachricht How to track and trace a protein: Nanosensors monitor intracellular deliveries
19.06.2018 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Creating a new composite fuel for new-generation fast reactors

20.06.2018 | Materials Sciences

Game-changing finding pushes 3D-printing to the molecular limit

20.06.2018 | Materials Sciences

Could this material enable autonomous vehicles to come to market sooner?

20.06.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>