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The Effect of Statins Influenced by Gene Profiles


The Montreal Heart Institute Research Centre is once again pushing the limits of knowledge in personalized medicine.

A meta-analysis combining the results of several pharmacogenomic studies and involving over 40,000 research subjects now makes it possible to demonstrate a different response to statins according to the patient's gene profile.

This important contribution of two Montreal researchers from the Montreal Heart Institute (MHI), Dr. Jean-Claude Tardif, Director of the Research Centre and Dr. Marie-Pierre Dubé, Director of the Pharmacogenomics Centre, was the subject of a scientific publication released today in the prestigious journal Nature communications.

"Once again, the Montreal Heart Institute and its team of committed doctors, researchers and professionals stand out as world leaders in the fight against cardiovascular diseases. This research project benefitted from our participation in this international consortium, leveraged by our knowledge and our pharmacogenomic laboratory dedicated to the search for innovative treatments in the fight against heart disease. 

Today, these advances make it possible to identify a different response to a statin commonly used to reduce LDL-cholesterol (bad cholesterol), according to the individual's gene profile. And for the first time, two genomic regions (loci) have been identified as determining responses to a statin," said Dr. Tardif as he highlighted the MHI Foundation's financial contribution towards the completion of this study.

Patients will benefit considerably in the medium and long term from these findings and innovations as the medical practices used to treat heart disease are transformed to allow each patient to receive suitable treatment. This is another of the MHI researchers' tangible contributions to the transformation of medical practices in the treatment of cardiovascular diseases.

Keep in mind that more than 1.3 million Canadians suffer from cardiovascular diseases, which are the world's primary cause of hospitalization and death. These diseases also put the greatest burden on our health system, with health costs nearing $22 billion per year.

About the Montreal Heart Institute

Founded in 1954 by Dr. Paul David, the Montreal Heart Institute fosters the highest standards of excellence in cardiology through its leadership in clinical and fundamental research, ultra-specialized care, professional training, and prevention. It is part of the vast network of excellence in health established by Université de Montréal and its affiliates. 

About the Montreal Heart Institute Foundation

The Montreal Heart Institute Foundation raises and administers funds to support the Montreal Heart Institute and its innovative and priority projects, and to assist the Institute in its fight against heart disease, the leading cause of death worldwide. Since its inception in 1977, the Foundation has granted more than $175 million to the Montreal Heart Institute.

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The study is available upon request.


Julie Chevrette                                    

Public Relations Officer

Montreal Heart Institute Foundation                          

514 376-3330, extension 2641 

Julie Chevrette | Eurek Alert!

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