A new study by medical researchers at LMU extends the list of tasks performed by the smallest blood cells known as platelets: At sites of infection, actively migrating platelets sweep bacteria into aggregates for disposal by phagocytic cells.
The active role of blood platelets in immune defense has been underestimated. A new study now published by LMU medical researchers led by Dr. Florian Gärtner and Professor Steffen Massberg, shows that this cell type has a larger range of functions than previously thought. Thrombocytes are best known for their role in blood coagulation and wound-healing. But they are not only adept at patching up tears in the endothelial cell layer that lines the blood vessels.
"They are also important in defending the organism against bacterial pathogens. They have the capacity to actively migrate within the organism, to interact with pathogens and immobilize them." This is lead author Florian Gärtner's summary of the major findings of a study that has just appeared in the leading journal Cell.
Some 750 billion platelets are passively transported in the bloodstream throughout the adult human body. Platelets adhere specifically to sites in the vasculature where the endothelial cells have been damaged by binding via surface receptors to proteins in the sub-endothelial cell layer.
They then spread out on the extracellular matrix, and interact with one another to form a network that acts like a sticking plaster to seal the wound. Furthermore, they are intimately involved in initiating blood coagulation at wound sites, but also in the development of blood clots (thromboses) which can obstruct blood circulation.
In a project carried out under the auspices of the DFG-funded Collaborative Research Center (Sonderforschungsbereich) SFB 914 (which focuses on the investigation of immune cell migration in inflammation, development and disease) Gärtner, Massberg and colleagues recently developed a way to track individual platelets at the site of an inflammatory reaction for extended periods. These observations revealed an unsuspected function of this cell type.
"Not only do they attach to bacterial cells by passively sticking to the vascular wall, they are also capable of active locomotion," says Gärtner. At sites of inflammation or infection, platelets begin to actively explore their immediate environment, and when they come into contact with foreign bodies, such as invasive bacteria, they use the traction associated with locomotion to collect them into bundles, rather like street-sweepers clearing up debris. The resulting platelet-bacterial aggregates facilitate the activation of neutrophils, which engulf the trapped microbes.
The reason why the versatility of platelets has so far been overlooked may well lie in the fact that they are derived from giant precursor cells called megakaryocytes by fragmentation, and therefore lack nuclei. The work of Gärtner und Massberg demonstrates that they are nevertheless capable of undergoing dynamic shape change and active migration.
This finding has implications that extend beyond their role in immune defense, because it reveals what anucleate cells can do. "This is a very striking demonstration that the cytoskeletal apparatus responsible for cell motility does not depend on the presence of a nucleus," Gärtner says.
In addition, the new results make platelets an attractive target for drug developers searching for novel ways to treat inflammation reactions. As Gärtner points out, "one way to modulate the action of the body's immune defenses would be to inhibit the ability of platelets to migrate."
Dr. Florian Gärtner | EurekAlert!
More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
19.01.2018 | Materials Sciences
19.01.2018 | Health and Medicine
19.01.2018 | Physics and Astronomy