Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


TGen-ASU researchers find tiny genetic switches in lizard tail regeneration


Findings from lizards may impact future therapies to regrow organs in humans

Any kid who pulls on a lizard tail knows it can drop off to avoid capture, but how they regrow a new tail remains a mystery. Now, researchers at the Translational Genomics Research Institute (TGen) and Arizona State University (ASU) have identified tiny RNA switches, known as microRNAs, which may hold the keys to regenerating muscles, cartilage and spinal columns.

In a study published today in the scientific journal BMC Genomics, ASU and TGen scientists for the first time identified three microRNA's -- a which turn genes on and off -- that are associated with the regeneration of tails in the green anole lizard, Anolis carolinensis.

Courtesy of Dr. Kenro Kusumi

In a study published today in the scientific journal BMC Genomics, ASU and TGen scientists for the first time identified three microRNAs -- which turn genes on and off -- that are associated with the regeneration of tails in the green anole lizard, Anolis carolinensis.

Using next-generation genomic and computer analysis, this interdisciplinary team of scientists hope their findings, following nearly 6 years of research, will help lead to discoveries of new therapeutic approaches to switch on regeneration genes in humans.

"Since microRNAs are able to control a large number of genes at the same time, like an orchestra conductor leading the musicians, we hypothesized that they had to play a role in regeneration," said senior author Dr. Kenro Kusumi, a Professor in ASU's School of Life Sciences and Associate Dean in the College of Liberal Arts and Sciences, and an adjunct faculty member at TGen. "Our earlier work found that hundreds of genes are involved in regeneration, and we are very excited to study these three new microRNAs."

Dr. Elizabeth Hutchins, a Post-Doctoral Fellow in TGen's Neurogenomics Division, and co-lead author of the study, said she hopes this investigation eventually enables such things as regenerating cartilage in knees, repairing spinal cords in accident victims, and reproducing the muscles of injured war veterans.

"It is the translational nature of this work -- how it could eventually be applied to people -- that led to my interest in this study," said Dr. Hutchins, who graduated from ASU's Molecular and Cellular Biology Program. "For example, we currently don't have the ability to regrow knee cartilage, which would really help someone like my grandmother."

"This work highlights the importance of tiny RNA molecules in the tissue regeneration process, and showed for the first time an asymmetric microRNA distribution in different portions of the regenerating lizard tails," said Dr. Marco Mangone, a co-author and Assistant Professor with ASU's School of Life Sciences and Biodesign Institute. "It seems like microRNAs may play an active role in this process, and are potentially able to shape the regenerating lizard tail like playdough."

The research team also included: Dr. Justin Wolter of ASU's Biodesign Institute and School of Life Sciences; and Dr. Walter Eckalbar at the University of California, San Francisco.


This research was funded by grants from the National Institutes of Health and the Arizona Biomedical Research Commission.

About TGen

Translational Genomics Research Institute (TGen) is a Phoenix, Arizona-based non-profit organization dedicated to conducting groundbreaking research with life changing results. TGen is focused on helping patients with neurological disorders, cancer, and diabetes, through cutting edge translational research (the process of rapidly moving research towards patient benefit). TGen physicians and scientists work to unravel the genetic components of both common and rare complex diseases in adults and children. Working with collaborators in the scientific and medical communities literally worldwide, TGen makes a substantial contribution to help our patients through efficiency and effectiveness of the translational process. For more information, visit: Follow TGen on Facebook, LinkedIn and Twitter @TGen.

About ASU

ASU's School of Life Sciences is an academic unit of the College of Liberal Arts and Sciences.

Arizona State University is the largest public research university in the United States under a single administration, with total student enrollment of more than 70,000 in metropolitan Phoenix, the nation's sixth-largest city. ASU is creating a new model for American higher education, an unprecedented combination of academic excellence, entrepreneurial energy and broad access. This New American University is a single, unified institution comprising four differentiated campuses positively impacting the economic, social, cultural and environmental health of the communities it serves. Its research is inspired by real-world application, blurring the boundaries that traditionally separate academic disciplines. ASU champions intellectual and cultural diversity, and welcomes students from all 50 states and more than 120 nations.



Steve Yozwiak

ASU School of Life Sciences

Sandy Leander

Steve Yozwiak | EurekAlert!

More articles from Life Sciences:

nachricht Don't Give the Slightest Chance to Toxic Elements in Medicinal Products
23.03.2018 | Physikalisch-Technische Bundesanstalt (PTB)

nachricht North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Space observation with radar to secure Germany's space infrastructure

Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.

The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...

Im Focus: Researchers Discover New Anti-Cancer Protein

An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.

The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

New solar solutions for sustainable buildings and cities

23.03.2018 | Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

Latest News

For graphite pellets, just add elbow grease

23.03.2018 | Materials Sciences

Unique communication strategy discovered in stem cell pathway controlling plant growth

23.03.2018 | Agricultural and Forestry Science

Sharpening the X-ray view of the nanocosm

23.03.2018 | Physics and Astronomy

Science & Research
Overview of more VideoLinks >>>