Tapeworms live in the intestines and absorb nutrients from their hosts without doing any major harm. Their larvae, in contrast, are much more dangerous. They can migrate to the liver, lung, brain or other organs and form cysts in these tissues which can grow to the size of a handball. These cysts can have severe consequences for the infected persons, such as blindness, epilepsy, liver failure and even death.
In this stage, the larva of a fox tapeworm enters the fox that has eaten an infected mouse. In the centre of the globular structure, we can see more clear-cut bends: This is the set of hooks the tapeworm uses to attach to the intestinal wall of the fox. (Photo: Klaus Brehm)
Fox tapeworm kept in the lab: The larval stages are cultivated in the lab. In the liver of the intermediate hosts they grow like a tumor. This system was developed at Würzburg University. It allows testing which drugs kill the parasite, among others. (Photo: Klaus Brehm)
Professor Klaus Brehm of the University of Würzburg estimates that several hundred million people worldwide are infected by tapeworms – especially in the tropics, and especially in regions where people live closely together with animals under poor hygienic conditions. According to Brehm, no therapy is presently available that reliably kills the dangerous tapeworm larvae.
Fascinating results in "Nature"
Against this background, an international research team has now presented fascinating new insights into tapeworms in the top science magazine "Nature". Besides scientists from England and Mexico, a team of the University of Würzburg has been a major contributor to the study: Klaus Brehm and his associates Ferenc Kiss and Uriel Kozial of the Institute for Hygiene and Microbiology.
The researchers have sequenced the genome of fox tapeworm, pork tapeworm, dog tapeworm and dwarf tapeworm for the first time. "The DNA sequences now help us find potential drug targets on which therapies can act", says Dr Matthew Berriman of the Sanger Institute in Hinxton near Cambridge (England). Normally, researchers identify new targets for drugs to combat diseases by comparing a pathogen's genome sequence with the human host's DNA to find differences between them. This time, however, researchers deliberately looked for similarities: They wanted to identify new targets for drugs which have already proved effective in other conditions.
Cancer drugs to fight tapeworms
A list of the most promising targets shows: Many are identical to targets on which cancer treatments take effect. The reason: "A tapeworm infection takes a course much like the growth of a tumour", Brehm explains. "The larvae of the fox tapeworm, for instance, metastasise and proliferate in the whole body." Additionally, their development is controlled by the same genes responsible for the growth of a cancer cell. The larvae are therefore probably susceptible to standard cancer treatments.
Proteins as possible targets
But the researchers uncovered even more weak spots of the parasites. In the course of evolution, tapeworms have lost the ability to synthesise the necessary fats and cholesterol that are crucial for larvae development. Instead, they scavenge from their hosts. They use proteins to bind the necessary fats. By attacking these proteins with certain drugs, researchers hope to "starve" the larvae.
Tests on cell cultures of tapeworms
But are the identified new targets really weak spots of the tapeworms? This is currently being studied at the University of Würzburg. Klaus Brehm and his team have done pioneering work here to develop methods to cultivate the cells of fox tapeworm in the laboratory. "This enables us to test the potential drugs and select the most effective ones for further studies."
Reason for failure discovered
The genome analysis has shown why treatment attempts so far have been unsuccessful. The drug Praziquantel, for instance, which blocks certain calcium channels, had been used to combat the tapeworm larvae. It reliably kills the tapeworm species living in the intestines, but is ineffective against larvae – because said channels hardly exist in the larvae, as has been discovered recently.
Fascination tapewormKlaus Brehm and his team at the University of Würzburg study other aspects of tapeworms which might be important for medical progress.
"The tapeworm larvae behave like perfect transplants", the Würzburg scientist explains. "They implant themselves in the liver, for example, where they grow over years without the immune system noticing". If scientists knew how this perfect camouflage against the immune system works, major advances could be achieved in organ transplantation. Because transplanted organs are frequently rejected by the recipient's immune system.
Brehm is also fascinated by another characteristic of the parasites: "A tapeworm is theoretically immortal". How is that possible? The tapeworms fertilise themselves in their final host's intestine and their eggs pass into the environment with the host's faeces. The eggs are eaten by the intermediate hosts, transform into larvae and end up in the final host again – an endless cycle. "We want to learn how that works", Brehm says. The genome analysis has already yielded one new finding for the Würzburg scientists: "Tapeworms have a very special stem cell system which we will continue to study now".
“The genomes of four tapeworm species reveal adaptations to parasitism”, Nature, March 13, 2013, DOI: 10.1038/nature12031
Prof. Dr. Klaus Brehm, Institut für Hygiene und Mikrobiologie, Universität Würzburg, phone +49(0)931) 31-46168, firstname.lastname@example.org
Robert Emmerich | Uni Würzburg
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy