Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Signal for Embryological Development

21.03.2016

The protein YAP plays a crucial role in the development of the human neural crest

To grow or to specialise? To remain stationary or initiate migration? How do cells know what to do and how they should develop? The Hippo/YAP signalling pathway plays a crucial role when the cells of the neural crest – a structure that generates cell types such as bones and nerve tissue – specialise for a certain function in the human embryo and migrate to their target region within the body.


Neuroblastoma cells: These tumours can be caused by processes involving the Hippo/YAP signalling pathway. Source: Pruszak lab

That is what the researchers Alexandra Larisa Condurat, Dr. Christopher J. Hindley, Vishal Menon, Dr. Jan Pruszak and Ria Thomas from the University of Freiburg have shown in a study that has been published in the open access journal „Scientific Reports“.

The team’s insights are relevant for an enhanced understanding of neural crest developmental processes and associated disorders, such as neurocristopathies. They may also further elucidate cellular processes that cause cancers such as neuroblastoma or that enable cells to integrate local signals from their environment.

... more about:
»CANCER »cell types »neural »retinoic

Human embryological development requires a strict sequence of tightly coordinated processes that are regulated by complex signalling networks. Early on in vertebrate ontogenesis, the neural crest arises – a cell population that generates an unrivalled diversity of cell types including bone, cartilage, smooth muscle and nerve tissues.

Originating from the back of the tube-like structure that will give rise to the spinal cord and brain, the neural crest cells change their morphology, eventually detach from their origin and, further specialising, migrate to their various target regions within the body. The Hippo/YAP signalling pathway integrates local signals from its environment to regulate proliferation, that is cell growth, in a variety of stem cell and tissue systems including skin, intestine and liver.

The researchers from the University of Freiburg have analysed in human stem cells and cancer cell lines the role that the Hippo/YAP signalling pathway plays in the differentiation and development of the human neural crest. They found that YAP is associated with the neural cells’ stemness and is preventing their development into specialised cells. The scientists have furthermore observed another cell population that is characterised by a high activity of YAP. In this population, the combination of molecules at the cell surface is altered. A metabolite of vitamin A, retinoic acid, is known for influencing neural crest cells. As the researchers have shown in cell models, YAP and retinoic acids are jointly promoting neural crest migratory properties.

Jan Pruszak is a member of the Cluster of Excellence BIOSS Centre for Biological Signalling Studies at the University of Freiburg, as well as a junior group leader in the Emmy-Noether-Program of the German Research Foundation at the Institute of Anatomy and Cell Biology, University of Freiburg. Alexandra Larisa Condurat, Vishal Menon und Ria Thomas belong to Pruszak’s research group and are graduate students at the Spemann Graduate School of Biology and Medicine. Christopher Hindley was supported by a postdoctoral fellowship of the Alexander von Humboldt-Foundation during his stay in the Pruszak lab. He is now at the Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge/United Kingdom.

Original publication:
Christopher J. Hindley, Alexandra Larisa Condurat, Vishal Menon, Ria Thomas, Luis M. Azmitia, Jason A. Davis, Jan Pruszak (2016). The Hippo pathway member YAP enhances human neural crest cell fate and migration. Scientific Reports 6. doi: 10.1038/srep23208


Contact:
Dr. Jan Pruszak
Department of Molecular Embryology
University of Freiburg
Phone: +49 (0)761 / 203 - 5121
E-Mail: jan.pruszak@uniklinik-freiburg.de

Weitere Informationen:

https://www.pr.uni-freiburg.de/pm/2016/pm.2016-03-21.39-en?set_language=en

Rudolf-Werner Dreier | idw - Informationsdienst Wissenschaft

Further reports about: CANCER cell types neural retinoic

More articles from Life Sciences:

nachricht The birth of a new protein
20.10.2017 | University of Arizona

nachricht Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>