Due to their nanoscale dimensions and sensitivity to light, quantum dots are being used for a number of bioimaging applications including in vivo imaging of tumor cells, detection of biomolecules, and measurement of pH changes.
When quantum dots are introduced in biological media, proteins surround the nanoparticles and form a corona. The formation of the protein corona changes the sensitivity of the quantum dots to light.
Using the cadmium selenide quantum dot, researchers at Syracuse University collaborated to understand how protein corona forms and what is different about the quantum dot before and after the formation of the corona.
Research performed by Professor Shikha Nangia, in the Department of Biomedical and Chemical Engineering, and Professor Ari Chakraborty, in the Department of Chemistry, resulted in the development of a novel multilevel computational approach.
This method combines the strengths of quantum mechanics, molecular mechanics, classical molecular dynamics, and Monte Carlo techniques. Because of this work, it is now possible to perform computer simulation of protein-quantum dot complexes that were previously considered to be beyond the scope of computational investigations. Now that this methodology has been created, it can be applied to bigger and more complex quantum dot systems.
Their paper, "Optical Signature of Formation of Protein Corona in the Firefly Luciferase-CdSe Quantum Dot Complex" is featured on the cover of the January issue of the Journal of Chemical Theory and Computation.
Matt Wheeler | EurekAlert!
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The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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