Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Sexually-transmitted diseases: do multiple partners mean more immunity?


It has been assumed that the increased transmission of sexually-transmitted diseases in the case of mating promiscuity is influential in shaping the immune system of mammals. Results published in the scientific journal “Functional Ecology” this week demonstrate that this simple idea does not apply to rodents, and that living circumstances and the environment can be a key factor in determining variation in immune investment among mammals.

It has been assumed that the increased transmission of sexually-transmitted diseases in the case of mating promiscuity is influential in shaping the immune system of mammals. Results published in the scientific journal “Functional Ecology” this week demonstrate that this simple idea does not apply to rodents, and that living circumstances and the environment can be a key factor in determining variation in immune investment among mammals.

A young brown rat (Rattus norvegicus).

Photo: IZW/Jundong Tian

The immune system protects organisms against diseases. Therefore, detecting the factors which shape this system is of great interest to both human and animal medical science. One major question is whether exposure to sexually-transmitted diseases is a main force driving variation in mammalian immunity. Some evidence suggested that this was the case for primates and carnivores and until now was thought to apply to all mammals. Researchers from the German Leibniz Institute for Zoo and Wildlife Research (IZW) have now shown that for rodents, representing 40 % of all living mammal species, this is not the case.

In order to assess the ‘sexually-transmitted diseases’ hypothesis, scientists from the IZW retrieved data from 145 published studies on rodents. They used the number of total white blood cells and their two main components, neutrophils and lymphocytes, as measures of immunity. They quantified the risk of sexually-transmitted diseases by using measures of testes mass, a known predictor of the number of mating partners across species.

The effects of body mass differences and the living circumstances (captive vs. free-ranging) were also taken into consideration in the analyses. The findings demonstrated that large species displayed an increase in the number of immune cells. Also, individuals from captive populations exhibited higher lymphocyte counts than individuals from free-ranging ones. However, testes mass did not vary with immunity, which suggests that sexually-transmitted diseases do not play a major role in shaping the rodent immune system.

“As we know that the prevalence of sexually transmitted pathogens as well as immunological parameters can differ between mammalian groups, pressure by sexually-transmitted diseases may not be the primary determinant of driving immune function in all mammals”, says Jundong Tian, lead author of the study. “Moreover, there is also substantial evidence for effects of captivity upon the physiology of organisms. This suggests that findings derived from captive populations need to be considered very cautiously if we want to understand how evolutionary forces have acted on the immune system over millions of years”, comments Gábor Czirják, principal investigator of the study.

Identifying factors which shape immunity in mammals is likely to ultimately lead to advances in medical treatment. Studies applied to rodents are particularly important in this respect, as mice and rats – key representatives of this mammalian group – continue to serve as a major model animal source for biomedical research.

Tian JD, Courtiol A, Schneeberger K, Greenwood AD, Czirják GÁ (2014): Circulating white blood cell counts in captive and wild rodents are influenced by body mass rather than testes mass, a correlate of mating promiscuity. FUNCTIONAL ECOLOGY. Doi:10.1111/1365-2435.12394

Jundong Tian, +49 30 5168 227,
Gabor Á Czirják , +49 30 5168 214,
Prof Alex D Greenwood, +49 30 5168 255,
Steven Seet, +49 30 5168 125,

Leibniz Institute for Zoo- and Wildlife Research (IZW)
in Forschungsverbund Berlin e.V.
Alfred-Kowalke-Str. 17
10315 Berlin

The Leibniz Institute for Zoo and Wildlife Research (IZW) investigates the vitality and adaptability of wildlife populations in mammalian and avian species of outstanding ecological interest that face anthropogenic challenges. It studies the adaptive value of traits in the life cycle of wildlife, wildlife diseases and clarifies the biological basis and development of methods for the protection of threatened species. Such knowledge is a precondition for a scientifically based approach to conservation and for the development of concepts for the ecologically sustainable use of natural resources.

Weitere Informationen:

Karl-Heinz Karisch | Forschungsverbund Berlin e.V.

Further reports about: IZW Wildlife Wildlife Research body mass diseases immune system immunity mammalian species

More articles from Life Sciences:

nachricht Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München

nachricht Second research flight into zero gravity
21.10.2016 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>