Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Salicylic acid, a widespread ingredient in pain relief medication, promotes nasal mucosa colonizati

03.02.2017

Salicylic acid is a plant hormone best known for its use as a key ingredient in pain relievers, anti-acne preparations and medications for skin conditions. We also consume mild doses of salicylic acid when we eat fruits and vegetables. Researchers, including scientists from Vetmeduni Vienna, have now shown that the multifaceted compound can also have an unpleasant side effect. Salicylic acid forms complexes with iron, an important trace element. Laboratory tests showed that iron limitation strongly promotes the formation of biofilms by S. aureus. This allows the bacteria to persist in our respiratory tract possibly causing infections. Published in Frontiers in Microbiology.

Staphylococcus aureus (S. aureus ) can colonize the upper respiratory tract of around one quarter of the human population. As an opportunistic bacteria S. aureus usually does not harm its host. If the host is healthy and the bacteria obtain sufficient nutrients, the bacteria remain quiet and are kept under control by the immune system. They may, however, become active in response to infections by another pathogen or illness weakening the host immune system.


Salicylic acid complexes iron and thus limits the substance for S. aureus colonies. This promotes the formation of biofilms.

Tom Grunert/Vetmeduni Vienna

The regular consumption of salicylic acid, or its consumption in higher doses, could unexpectedly promote and prolong bacterial colonization, as shown by a joint study conducted by Monika Ehling-Schulz’s group from the Institute of Microbiology, Vetmeduni Vienna, together with the research group of Fernanda Buzzola from the University of Buenos Aires. The research stays were in part funded by the Mobility Programme for Scientific and Technological Cooperation between Austria and Argentina.

Salicylic acid deprives the body of iron and triggers a defence mechanism in the bacteria

Iron is an important trace element for the human body and plays an essential role in blood formation. The metabolism of many bacteria, including S. aureus, also depends on the availability of iron molecules. Salicylic acid forms complexes with iron ions in the blood and so deprives not only us but also the staphylococcal bacteria of this element.

S. aureus modifies its metabolism if it obtains no or only insufficient iron. The microorganism reacts to the changed – from its perspective, negative – conditions through the intensified formation of a biofilm, a sort of layer of slime formed by the aggregation of individual bacteria, as Tom Grunert of the Institute for Microbiology at Vetmeduni Vienna explains. The accelerated biofilm production allows the bacteria to survive for an even longer period under unfavourable living conditions.

This increased biofilm formation is promoted by the regular or increased consumption of salicylic acid. As pain relief medication, this compound is usually not taken regularly. However, it also is a component of anti-acne preparations and certain exfoliate products, which are often used for a longer period of time. Since salicylic acid is found in fruits and vegetables, people who follow a mostly vegetarian diet might also affected. “These people consume a small dose of the substance virtually every day,” says Grunert. The use of certain medications further increases the iron limitation. Taken orally, salicylic acid enters the blood circulation and forms there complexes with the iron ions.

Enhanced biofilm formation after consumption of salicylic acid in experimental settings

The research team demonstrated this effect in a laboratory experiment. “We first confirmed that salicylic acid, which is known for its capacity to form iron complexes, really does ‘capture’ the iron that is important for the staphylococcal bacteria,” says Grunert. The formation of the bacterial biofilm was then demonstrated through different doses of salicylic acid. “We grew a staphylococcal culture in a special, iron-rich medium – a nutrient solution – in a laboratory dish.” The addition of salicylic acid resulted in a further increase of biofilm. Moreover, the treatment of mice with salicylic acid demonstrably resulted in prolonged colonization of the nasal mucosa by S. aureus.

“We were able to show that the frequent consumption of salicylic acid as well as a vegetarian diet can promote the colonization of the upper respiratory tract by S. aureus, which may contribute to staphylococcal infections that are long lasting and more difficult to treat” explains Grunert.

Service:
The article “The Active Component of Aspirin, Salicylic Acid, Promotes Staphylococcus aureus Biofilm Formation in a PIA-dependent Manner” by Cristian Dotto, Andrea Lombarte Serrat, Natalia Cattelan, María S. Barbagelata, Osvaldo M. Yantorno, Daniel O. Sordelli, Monika Ehling-Schulz, Tom Grunert and Fernanda R. Buzzola was published in Frontiers in Microbiology.
http://journal.frontiersin.org/article/10.3389/fmicb.2017.00004/full

About the University of Veterinary Medicine, Vienna
The University of Veterinary Medicine, Vienna in Austria is one of the leading academic and research institutions in the field of Veterinary Sciences in Europe. About 1,300 employees and 2,300 students work on the campus in the north of Vienna which also houses five university clinics and various research sites. Outside of Vienna the university operates Teaching and Research Farms. http://www.vetmeduni.ac.at

Scientific Contact:
Tom Grunert
Institute of Microbiology
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 1 25077-2469
tom.grunert@vetmeduni.ac.at

Released by:
Georg Mair
Science Communication / Corporate Communications
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 1 25077-1165
georg.mair@vetmeduni.ac.at

Weitere Informationen:

http://www.vetmeduni.ac.at/en/infoservice/presseinformation/press-releases-2017/...

Mag.rer.nat Georg Mair | idw - Informationsdienst Wissenschaft

Further reports about: Veterinary Medicine bacteria mucosa pain relief salicylic acid

More articles from Life Sciences:

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
22.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>