Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Road map to a longer life

06.10.2017

Tissues respond very differently to an ageing ameliorating intervention

In old age a variety of cellular processes decline and the risk to develop age-related diseases such as Alzheimer’s, Parkinson’s or Diabetes increases dramatically. But does ageing affect all organs and tissues in the body in the same way? And should drugs that are developed to improve health in old age have the same effect on every organ?


The model organism Drosophila melanogaster is used to map the tissue-specific responses to insulin signalling.

@Tain/Groenke/Link/Max Planck Institute for Biology of Ageing

Now scientists from the Max Planck Institute for Biology of Ageing in Cologne have shown in flies that tissues respond very differently to reduced insulin signalling, which is known to extend lifespan in many organisms, from flies to mice, and possibly people. Importantly, those different responses can lead to extensions in lifespan themselves.

Scientists have known for many years that lowered activity of the insulin signalling network can extend lifespan and improve health during ageing, but it is still not understood how. The insulin signalling network responds to nutrient availability and stress levels and regulates development, growth, reproduction and lifespan.

To understand how different tissues and organs respond, researchers in the team of Linda Partridge, director at the Max Planck Institute for Biology of Ageing and the UCL Institute of Healthy Ageing in London, analysed which proteins are produced in the brain, muscle, gut and fat body of fruit flies when insulin signalling is reduced. With this they generated a proteomic map of insulin signalling.

Each tissue responds differently

“We mapped out which proteins changed in which tissues when insulin signalling is reduced and could see that each tissue in the fly responds differently. There were only two proteins out of 6000 we analysed, which were regulated in all tissues - all others were to some degree tissue-specific”, explains Luke Tain, lead author of the study.

“For example, if we reduce systemic insulin signalling, the gut responds by producing proteins for ensuring protein quality control.” This response of the gut can lead to an extension in lifespan itself: even without lowered activity of the insulin network, an increasing protein quality control only in the gut was sufficient to prolong lifespan in flies. However, the same treatment in the fat of the fly had no effect on its lifespan.

Tissue-targeted pharmacological agents

These results show how complex the response of different organs to interventions that improve health during ageing can be. “Our study opens up new possibilities for development of preventive medicine for diseases associated with ageing. In the future we could target a specific tissue with a drug, to the benefit of the whole organism. This would reduce the risk of unwanted side effects and alleviate a lot of the suffering in patients and the aged”, says Tain.

Weitere Informationen:

https://www.age.mpg.de/public-relations/press-material/press-releases/detail/new...
http://msb.embopress.org/content/13/9/939.long

Dr. Maren Berghoff | Max-Planck-Institut für Biologie des Alterns

More articles from Life Sciences:

nachricht Tag it EASI – a new method for accurate protein analysis
20.06.2018 | Max-Planck-Institut für Biochemie

nachricht How to track and trace a protein: Nanosensors monitor intracellular deliveries
19.06.2018 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Creating a new composite fuel for new-generation fast reactors

20.06.2018 | Materials Sciences

Game-changing finding pushes 3D-printing to the molecular limit

20.06.2018 | Materials Sciences

Could this material enable autonomous vehicles to come to market sooner?

20.06.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>