Researchers Develop Method for Mapping Neuron Clusters

“We have established a method to find functional groupings of neurons based on co-fluctuation of their responses,” says Roozbeh Kiani, an assistant professor in NYU’s Center for Neural Science and one of the study’s authors. “In doing so, we show that PFC neurons are organized into spatially contiguous maps, much like their counterparts in sensory cortices. The widely accepted notion that orderly spatial maps are restricted to sensory cortices, therefore, needs revision.”

“Our methodology is closely related to the techniques that led to the discovery of functional networks in brain imaging studies,” adds William Newsome, a professor of neurobiology at Stanford University and a Howard Hughes Medical Institute Investigator. “There is, however, a crucial difference. We extend the methodology to cellular scale and demonstrate that it can be used for identifying networks at a neuronal level. By suggesting a potential neural substrate for functional networks in macro-scale brain imaging we bridge a critical gap in our knowledge.”

The research focused on the “parcellation” of PFC neurons: how these cells are grouped together to perform specific functions. The scientists showed that the discovered subnetworks in the prefrontal cortex are linked to the decision-making behavior but seem to have distinct roles: one subnetwork better represents upcoming choices and another one seems to keep track of past choices.

Previous studies that explored spatial organization of neurons in the prefrontal cortex predominantly focused on the average responses of neurons by examining them one at a time. They missed the organization of the network “forest” for the neuron “trees”. In the Neuron paper, the researchers outlined a vastly different method. In it, they focused on the correlated activity of large numbers of simultaneously recorded neurons to spot the larger “topography” of the network—and how their groupings may be linked to the behavior. Specifically, they applied clustering algorithms that discover natural divisions in the matrix of response correlations to divide the recorded neural population.

“This technique provides an innovative, but straightforward, way to delineate cortical networks,” observers Kiani. “The subnetworks in the PFC are stable across behavioral tasks and are apparent even in the spontaneous fluctuations of neural responses. They seem to be largely defined by the intrinsic connectivity of neurons in the local network. Therefore, they provide an objective basis for dividing the cortex into constituent subnetworks, offering a common standard across experiments.”

The study’s other authors include Diogo Peixoto and Christopher Cueva from Stanford University’s Department of Neurobiology and Stephen Ryu, M.D., from the Palo Alto Medical Foundation’s Department of Neurosurgery.

The research was funded, in part, by Howard Hughes Medical Institute, Simons Collaboration on the Global Brain, and the Air Force Research Laboratory (FA9550-07-1-0537).

Contact Information
James Devitt
Deputy Director for Media Relations
james.devitt@nyu.edu
Phone: 212-998-6808

Media Contact

James Devitt newswise

More Information:

http://www.nyu.edu

All latest news from the category: Life Sciences and Chemistry

Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Back to home

Comments (0)

Write a comment

Newest articles

Lighting up the future

New multidisciplinary research from the University of St Andrews could lead to more efficient televisions, computer screens and lighting. Researchers at the Organic Semiconductor Centre in the School of Physics and…

Researchers crack sugarcane’s complex genetic code

Sweet success: Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants….

Evolution of the most powerful ocean current on Earth

The Antarctic Circumpolar Current plays an important part in global overturning circulation, the exchange of heat and CO2 between the ocean and atmosphere, and the stability of Antarctica’s ice sheets….

Partners & Sponsors