Since then, the cells have become a household word, a source of hope for the afflicted, and a boon to biologists and biology everywhere. The cells, which in nature exist for only a fleeting period before marching down different development pathways to become any of the 220 types of cells of the human body, had been shown by Wisconsin developmental biologist Jamie Thomson to be controllable in the lab dish.
The feat was hailed as a remarkable biomedical coup, a development that would one day revolutionize transplant therapy by making unlimited amounts of cells of all types available for transplant, and as a crucible for drug discovery and window to the earliest stages of human development.
In the following decade, the all-purpose cells have also become politicized and industrialized. In the laboratory, scientists have directed blank-slate stem cells to become blood cells, neurons, and beating heart cells. Stem cells and their derivatives are used in industry as high-throughput screens to test drugs for efficacy and toxicity.
The list of stem cell milestones in both science and society is long and diverse. Here are a few.
-- Nov. 6, 1998: Publication in the journal Science of the seminal paper announcing the first successful derivation and sustained culturing of human embryonic stem cells.
-- Sept. 14, 1999: The Wisconsin Alumni Research Foundation establishes WiCell as a clearinghouse to distribute stem cells and foster research.
-- Aug. 9, 2001: President Bush announces his decision to limit federal funding for embryonic stem cell research to cell lines in existence at that point in time.
-- Sept. 4, 2001: A team of Wisconsin scientists led by Dan Kaufman announces it has coaxed stem cells to become blood cells.
-- Nov. 30, 2001: Neural progenitor cells, stem cells that have migrated part way down the developmental pathway to becoming specific types of brain cells, are created and implanted in mice where the cells further develop into functioning neurons. The work was conducted in the laboratory of UW-Madison stem cell scientist Su-Chun Zhang at the Waisman Center.
-- Feb. 10, 2003: Wisconsin scientists James Thomson and Thomas Zwaka report the ability to manipulate genes in human stem cells, a technique critical to studying gene function and creating cells to mimic disease in the lab dish.
-- June 26, 2003: Embryonic stem cells are coaxed to become heart muscle cells by a team led by UW-Madison cardiologist Timothy Kamp.
-- Nov. 2, 2004: California voters approve Proposition 71, which authorizes the state to spend $3 billion over ten years on embryonic stem cell research.
-- Nov. 20, 2004: Wisconsin Gov. Jim Doyle announces that Wisconsin will invest up to $750 million over several years in biomedical research, including new building initiatives and direct support for research. The announcement is the catalyst for the development of the public-private Wisconsin Institutes for Discovery.
-- Jan. 31, 2005: Wisconsin scientist Su-Chun Zhang creates the first spinal motor neurons.
-- Oct. 3, 2005: The National Institutes of Health names WiCell as the nation’s first National Stem Cell Bank.
-- Jan. 1, 2006: WiCell researchers announce the development of stem cell culture media free of animal products, a development necessary to culture cells for therapy in humans.
-- May 17, 2007: UW-Madison establishes the Stem Cell and Regenerative Medicine Center.
-- June 20, 2007: For the second time, President Bush vetoes legislation that would expand federal funding for human embryonic stem cell research.
-- Nov. 20, 2007: Two teams of researchers, including a Wisconsin team led by James Thomson and Junying Yu, show that skin cells can be genetically reprogrammed to behave like embryonic stem cells.
CONTACT: Timothy Kamp, (608) 263-4856, email@example.com; Clive Svendsen, (608) 265-8668, firstname.lastname@example.org
Terry Devitt | Newswise Science News
New type of photosynthesis discovered
17.06.2018 | Imperial College London
New ID pictures of conducting polymers discover a surprise ABBA fan
17.06.2018 | University of Warwick
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.
From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
15.06.2018 | Materials Sciences
15.06.2018 | Ecology, The Environment and Conservation
15.06.2018 | Power and Electrical Engineering