For decades, scientists have wondered how living organisms manufacture the essential vitamin B12. Now, using laundry whitener and dirt-dwelling bacteria—the everyday ingredients of an undergraduate science experiment—researchers may have found the major clue they need to solve the mystery.
Under ultraviolet light in a Petri dish containing laundry whitener, symbiotic bacteria with a mutant bluB gene (lower right) fluoresce brightly, while the same bacteria with no mutation only glow slightly (top right), and bacteria with another mutation (in the exoY gene) are completely dark.
Researchers led by Graham Walker, a Howard Hughes Medical Institute (HHMI) professor and American Cancer Society research professor at the Massachusetts Institute of Technology, have discovered the first known mutant bacteria with a specific defect in a gene involved in the least-understood part of B12 synthesis. They report their findings in the early online edition of the Proceedings of the National Academy of Sciences, published February 20, 2006. HHMI professors are leading research scientists who received $1 million grants from the Institute to find ways to bring the excitement of the research lab into undergraduate science classrooms.
In the ancient world, B12 was probably catalyzing reactions before cells even existed. Now, all animals need B12 to help make the building blocks of DNA, and children need enough of the vitamin to help their brain develop normally. Most people consume enough B12 through animal products or fortified foods in their diet. On the other hand, animals that do not eat other animal products acquire the nutrient from bacteria in their guts or from bacteria-infected dirt on their plant food. An estimated one-quarter of people older than 60 in this country have trouble absorbing B12. B12 deficiency can lead to nerve damage, anemia, and forgetfulness.
Jennifer Donovan | EurekAlert!
Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society
127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
18.01.2017 | Power and Electrical Engineering
18.01.2017 | Materials Sciences
18.01.2017 | Life Sciences