Study finds AKT blocks cancer cell motility; paradoxical discovery raises questions in developing cancer inhibitor therapies
In investigating the molecular mechanisms of cancer cell motility – the unique property that enables cancer to spread from its primary origin to other parts of the body – researchers have uncovered a surprising role for the AKT/PKB (protein kinase B) enzyme, providing important new insights into cancer metastasis and suggesting that current efforts to develop cancer therapies by inhibiting AKT may be inadvertently promoting the spread of the disease.
Led by a scientific team at Beth Israel Deaconess Medical Center (BIDMC) and described in a study in the Nov. 23 issue of the medical journal Molecular Cell, the research demonstrates for the first time that AKT, which is known to increase cancer cells survival capability also paradoxically increases their motility and invasion abilities, thereby preventing cancer from spreading.
Bonnie Prescott | EurekAlert!
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