Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Rational Design of Engineered Arginine Depleting Enzymes as Multi-potent Anti-cancer Agents

23.09.2016

A novel multi-potent drug removes arginine from the blood and kills cancer cells.

Arginine deprivation has become a new cancer treatment paradigm and has exploited for treatment of various cancers. Arginine is an essential amino acid for the growth of cancer cells. Deprivation of arginine induces cancer cells death but it is generally well tolerated in normal cells.


Three dimensional molecular structure of thermostable Bacillus arginase (BCA).

Copyright : PolyU

The successful use of Arginine Deiminase (ADI) to treat argininosuccinate synthetase (ASS)-deficient tumors has opened up new possibilities for targeted therapy. Nevertheless, many ASSpositive cancers are resistance to ADI.

By rational drug design, researchers at The Hong Kong Polytechnic University (PolyU) have developed a thermostable arginase (BCA-PEG20) to treat both ADI-sensitive and ADI-resistant cancers.

BCA-PEG20 has demonstrated to have antitumor activities both in vitro and in vivo in lung cancer, liver cancer, colorectal cancer, gastric cancer, cervical cancer and other tumors.

As a novel multipotent anti-cancer drug, BCA-PEG20 is able to work as a single agent and combine with other chemotherapeutic agents to enhance treatment effect.

Special Features
• BCA-PEG20 is safe and effective
• BCA-PEG20 can treat drug-resistant cancers
• BCA-PEG20 can augment the therapeutic effect of other chemotherapeutic agents

Applications
• As a multipotent targeted therapy for cancers that are auxotrophic for arginine
• As a “chemo-enhancer” to augment the effect of other chemotherapeutic agents

Prize of the State of Geneva (April 2009)
• Gold Award with the congratulations of the jury - 37th International Exhibition of I nventions, New Techniques and Products, Geneva (April 2009)
• Finalist Award- SEED Competition, China (2010)

Principal Investigator
Prof. Yun-chung LEUNG and Dr Wai-hung LO
Department of Applied Biology and Chemical Technology
The Hong Kong Polytechnic University
Contact Details:
Institute for Entrepreneurship
Tel: (852) 3400 2929 Fax: (852) 2333 2410 Email: pdadmin@polyu.edu.hk

Associated links

The Hong Kong Polytechnic University | Research SEA
Further information:
http://www.researchsea.com

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>