Researchers at the University of California, Riverside (UCR), have identified components in pomegranate juice that seem to inhibit the movement of cancer cells and weaken their attraction to a chemical signal that has been shown to promote the metastasis of prostate cancer to the bone, according to a presentation today at the American Society for Cell Biology's 50th Annual Meeting in Philadelphia.
The researchers in the UCR laboratory of Manuela Martins-Green, Ph.D., plan additional testing in an in vivo model for prostate cancer to determine dose-dependent effects and side effects of the two components.
The effect, if any, of pomegranate juice on the progression of prostate cancer is controversial.
In a 2006 study of prostate cancer patients who daily drank an eight-ounce glass of pomegranate juice, UCLA researchers detected a decline in prostate-specific antigen (PSA) levels that suggested a potential slowing of cancer progression.
The UCLA researchers did not try to define the potential biological mechanism behind pomegranate juice's effects in the study.
In Sept. 2010, the Federal Trade Commission (FTC) filed suit against Pom Wonderful, the natural foods company that provided the pomegranate juice for the UCLA research and has supported other research on pomegranate juice. The FTC charged the company with making false and misleading claims about the juice's effects on health.
In previous studies, Martins-Green and her research team used a standardized concentration of pomegranate juice on two types of laboratory-cultured prostate cancer cells that were resistant to testosterone.
Resistance to the hormone indicates a potentially strong metastatic potential. The researchers noted not only increased cell death among the pomegranate juice-treated tumor cells but also increased cell adhesion and decreased cell migration in those cancer cells that had not died.
The Martins-Green lab next analyzed the fruit juice to identify the active ingredients that had a molecular impact on cell adhesion and migration in metastatic prostate cancer cells. Martins-Green, graduate student Lei Wang and undergraduate student Jeffrey Ho identified phenylpropanoids, hydrobenzoic acids, flavones and conjugated fatty acids.
"This is particularly exciting because we can now modify these naturally occurring components of the juice to improve their functions and make them more effective in preventing prostate cancer metastasis," said Martins-Green.
"Because the genes and proteins involved in movement of prostate cancer cells are essentially the same as those involved in movement of other types of cancer cells, the same modified components of the juice could have a much broader impact in cancer treatment," she said.
For more information:
ASCB contacts:Cathy Yarbrough
John Fleischman | EurekAlert!
At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History
New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
16.02.2018 | Information Technology
16.02.2018 | Health and Medicine
16.02.2018 | Physics and Astronomy