Researchers from Freiburg have developed a sensor platform that quantifies antibiotics in human blood within minutes
A team of researchers from the University of Freiburg has developed a system inspired by biology that can detect several different antibiotics in human blood or other fluids at the same time. This biosensor system could be used for medical diagnostics in the future, especially for point-of-care testing in doctors’ practices, on house calls and in pharmacies, as well as in environmental and food safety testing. The researchers focused their study on the antibiotics tetracycline and streptogramin in human blood.
“The analysis takes only 10 minutes, from sample to result,” said the microsystems engineer Dr. Can Dincer, who is the head of the research team: “Our study was about demonstrating the applicability of the platform.”
The researchers have recently published their results in Analytical Chemistry. Based on these findings, the group is currently working on developing a method to determine how quickly the human body breaks down antibiotics, thus enabling the dosage of medications to be adjusted to each patient. “This technology could pave the way for personalized antibiotic treatments in the future,” Dincer said.
The all-too-frequent use of antibiotics in human and veterinary medicine causes pathogens to develop resistance. Multidrug resistant bacteria are the reason for an increasing number of life-threatening infections that are difficult to treat with medications available today.
In this context, biosensors have so much potential in research, since they are inexpensive and easy to work with. It is expected that biosensors can be employed to customize antibiotic treatments to fit each patient`s requirements, thereby decreasing the development of resistant bacteria in the future.
The electrochemical biosensor platform was developed by Prof. Dr. Gerald Urban’s research group. It works with extremely small amounts of liquid. “The major advantage of this system is that we can measure up to eight different substances at the same time, quickly and simply,” Dincer said. The researchers combined their chip technology with a method developed earlier by the bioengineering expert Prof. Dr. Wilfried Weber, also from the University of Freiburg.
The method is based on a naturally occurring sensor protein in resistant bacteria to recognize antibiotics and activate their defence mechanisms. These bacterial sensors react quickly, sensitively and specifically to antibiotics, which makes them ideal for analytical testing. Essentially, the bacteria are providing the researchers with a tool that can be applied to fight them back in the long-run.
The eight researchers from the University of Freiburg involved in the interdisciplinary study include Lucas Armbrecht, Dr. Can Dincer, Dr. Jochen Kieninger, André Kling, Edvina Qelibari and Prof. Dr. Gerald Urban – all from the Sensors Lab of the Department of Microsystems Engineering (IMTEK) – as well as Claire Chatelle and Prof. Dr. Wilfried Weber from the Synthetic Biology Department of the BIOSS Centre for Biological Signalling Studies cluster of excellence and the Faculty of Biology.
André Kling, Claire Chatelle, Lucas Armbrecht, Edvina Qelibari, Jochen Kieninger, Can Dincer, Wilfried Weber, and Gerald Urban, Multianalyte antibiotic detection on an electrochemical microfluidic platform, 2016 Anal. Chem., 88(20), 10036 - 10043. DOI: 10. 1021/acs. analchem. 6b02294
Dr. Can Dincer
Department of Microsystems Engineering – IMTEK
University of Freiburg
Phone: +49 (0)761 / 203 – 7264
Rudolf-Werner Dreier | idw - Informationsdienst Wissenschaft
Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care
Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
17.11.2017 | Physics and Astronomy
17.11.2017 | Health and Medicine
17.11.2017 | Studies and Analyses