Initial clinical tests show that biosensors could pave the way for a personalized antibiotherapy in the future
Personalized drug therapy, adjusting the dose, dosage intervals, and the duration of treatment to fit individual patients’ needs, are getting more and more important. Frequently, medications are dosed in such a way that each patient receives the same standardized amount of a certain drug.
Thereby, clinical conditions of the patient, such as state of health, metabolism, or other physical factors, are often not sufficiently considered. A researcher team at the University of Freiburg has developed a bioanalytical method which can measure the class of β-lactam antibiotics in human blood on-site – in the operating room, intensive ward or doctor's office, as well as on a house call.
“This way, we can easily determine just how quickly the human body metabolizes a drug,” said the microsystems engineer Dr. Can Dincer, who is the head of the research team. The researchers recently published their results in the journal “Scientific Reports”.
This new method makes it possible to individually adjust the necessary dose of a medication for each patient. “We’ve proven the applicability of our system for a personalized antibiotherapy by on-site monitoring the clearance of drugs in two patients, who were treated with ß-lactam antibiotics, undergoing surgery” Dincer said. “Based on these results, our next step will be to perform a quantitative cohort study that will determine the usefulness of personalized antibiotherapy.”, he added.
Already at the end of 2016, the research team presented its biosensor technology that allows the rapid and simultaneous monitoring of different antibiotics in human blood (www.pr.uni-freiburg.de/pm/2016/pm.2016-11-14.159). In their recently published study, the scientists further developed their system by implementing another natural sensor protein that can quantify β-lactam antibiotics. In human medicine, β-lactam antibiotics are often used to prevent and treat infectious diseases.
Nine researchers from the University of Freiburg were involved in this interdisciplinary study: Richard Bruch, André Kling, Dr. Can Dincer and Prof. Dr. Gerald Urban from the Laboratory for Sensors of the Department of Microsystems Engineering (IMTEK); Balder Rebmann, Dr. Claire Chatelle and Prof. Dr. Wilfried Weber from the Synthetic Biology Lab of the excellence cluster BIOSS Centre for Biological Signalling Studies and the Faculty of Biology; as well as Dr. Steffen Wirth and Prof. Dr. Stefan Schumann from the Department of Anesthesiology and Critical Care of the University of Freiburg Medical Center.
Richard, Bruch, Claire Chatelle, André Kling, Balder Rebmann, Steffen Wirth, Stefan Schumann, Wilfried Weber, Can Dincer, and Gerald Urban, Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy, 2017, Sci. Rep., 7, 3127, http://dx.doi.org/10.1038/s41598-017-03338-z.
Dr. Can Dincer
Department of Microsystems Engineering – IMTEK
University of Freiburg
Phone: +49 (0)761 / 203 - 7264
Rudolf-Werner Dreier | Albert-Ludwigs-Universität Freiburg im Breisgau
One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie
The dark side of cichlid fish: from cannibal to caregiver
20.04.2018 | Veterinärmedizinische Universität Wien
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Physics and Astronomy
20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy