Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New treatment strategies for chronic kidney disease from the animal kingdom

16.02.2018

The field of biomimetics offers an innovative approach to solving human problems by imitating strategies found in nature. Medical research could also benefit from biomimetics, as a group of international experts from various fields, including a wildlife veterinarian and wildlife ecologists from Vetmeduni Vienna, point out using the example of chronic kidney disease. In future research, they intend to study the mechanisms that protect the muscles, organs and bones of certain animals during extreme conditions such as hibernation. The possibilities were published in Nature Reviews.

Through certain genetic modifications, the process of evolution has resulted in a great variety of adaptations to different environments in the animal kingdom. Many species have developed fascinating mechanisms that provide resistance to disease or help protect their cells against ageing and oxidative stress in extreme conditions. It would therefore make sense to investigate these mechanisms in other species and adapt the insights gained to develop new strategies in the field of human medicine.


Biomimetics offers an innovative approach to solving human problems by imitating strategies of for example hibernators like bears found in nature.

Georg Rauer

An increased focus on biomimetics, the field of research that studies this approach, could lead to a medical breakthrough in the treatment of chronic kidney disease. An international, interdisciplinary research collaboration, including scientists from the Research Institute of Wildlife Ecology, has now provided an initial overview of which animal mechanisms could be useful for the development of new therapeutic approaches to this globally spreading disease.

Solutions sought for chronic kidney disease

Physical adaptations that are of interest to biomimetics include the outstanding longevity of naked mole rats, for example, or the ability to survive extreme conditions like hibernation. “Biomimetics attempts to copy strategies that have already been tried and perfected by nature over thousands of years,” explains Johanna Painer from the Department of Integrative Biology and Evolution.

Painer, in an international collaboration with experts from various different fields, researches which of these elements from the animal kingdom could be applied to human health. “We are comparing examples from human and veterinary medicine as well as from the field of biology to more quickly learn about the development of certain problems and then minimise them in the future,” the researcher says.

One of these problems for which solutions may be found in the animal kingdom is chronic kidney disease. This disease, which is becoming increasingly prevalent worldwide, is associated with many complications, such as cardiovascular disease, osteoporosis, muscle wasting and premature ageing. But kidney disease is also a problem in the animal kingdom. Domestic felines and wild cats are quite frequently affected by chronic kidney disease. “A possible cause is the high meat consumption and the resulting changes of the bacteria in the intestine,” says Painer. Other animals, like the common vampire bat or hibernators like the bear, have developed mechanisms that project them against the disease.

Future studies should investigate the mechanisms which, on the one hand, cause the disease in animals and, on the other hand, are responsible for certain protective effects. “Studies of felids may provide information on links between red meat consumption, gut microbiota and kidney disease. Studies of hibernating bears could help identify new strategies to treat and prevent complications such as muscle wasting, pressure ulcers, thrombosis and osteoporosis during longer periods of bedriddenness,” concludes Painer. New possibilities of organ preservation may also be found.

The advantage offered by biomimetics lies in its interdisciplinary nature. The collaboration between nephrologists – these are specialists in kidney disease and high blood pressure – and experts from other fields, such as veterinary medicine, zoology, molecular biology, anthropology and ecology, could introduce a novel approach for improving human health and help to find new treatment strategies for chronic kidney disease. “Collaboration between various disciplines creates a synergetic effect that may result in the discovery of many novel therapeutic approaches. We should make increased use of such collaboration in the future,” says Painer.

Service:
The article “Novel treatment strategies for chronic kidney disease: insights from the animal kingdom” by Peter Stenvinkel, Johanna Painer, Makoto Kuro-o, Miguel Lanaspa, Walter Arnold, Thomas Ruf, Paul G. Shiels and Richard J. Johnson was published in Nature Reviews.
https://www.nature.com/articles/nrneph.2017.169

About the University of Veterinary Medicine, Vienna
The University of Veterinary Medicine, Vienna in Austria is one of the leading academic and research institutions in the field of Veterinary Sciences in Europe. About 1,300 employees and 2,300 students work on the campus in the north of Vienna which also houses five university clinics and various research sites. Outside of Vienna the university operates Teaching and Research Farms. The Vetmeduni Vienna plays in the global top league: in 2017, it occupies the excellent place 8 in the world-wide Shanghai University veterinary in the subject "Veterinary Science". http://www.vetmeduni.ac.at

Scientific Contact:
Johanna Painer
Unit of Conservation Medicine
Research Institute of Wildlife Ecology
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 1 25077-7251
johanna.painer@vetmeduni.ac.at

Released by:
Georg Mair
Science Communication / Corporate Communications
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 1 25077-1165
georg.mair@vetmeduni.ac.at

Weitere Informationen:

https://www.vetmeduni.ac.at/en/infoservice/presseinformation/presse-releases-201...

Mag.rer.nat. Georg Mair | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

nachricht Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>